MS

Question 1

Diagnostic criteria of RRMS

Answer 1

1. demylinating CNS which are: disseminated in space (MRI/clinical) OR dissemintaed in time (MRI/cliical)

Question 2

define:

1. relapsing remitting

2. progressive MS

Answer 2

1. symptoms occur and then resolve

2. lesions occur but do not get resolved

Question 3

work-up for MS patient

Answer 3

1. MRI
2. CBC, CMP
3. B12, TSH, ESR, CRP
4. ANA, RF, anticardiolipin
5. LP (oligoclonal bands, IgG and cell count)
6. visual evoked potential
7. measure retinal nerve fiber layer thickness (optic coherence tomography)

Question 4

acute therapy versus chronic therapy of MS

Answer 4

acute: steroids, plasmapharesis
chronic: glatamir acetate, interferon, dimethyl fumarate, teriflunomide, fingolimod, natalizumab, alemtuzumab, ocrelizumab

Question 5

MS mimicker:

Answer 5

neuromyelitis optica- optic neuritis (both eyes)

Question 6

which HLA with MS

Answer 6

DRB1

Question 7

risk factors for mS

Answer 7

vit D deficiency, female, norther latitiude, mononucleiosis, smoking, obesity

Question 8

uhthoff phenomenoso

Answer 8

transient workening of symptoms with temperature

Question 9

lhermitte sign

Answer 9

paresthesia radiating down trunk when neck is f;exed

Question 10

diagnostic criteria of progressive MS

Answer 10

> 1 y progression

2 of 3 : DIS MRI brain, DIS MRI spine, +CSF

Question 11

name the side effect:

1. natalizumab
2. fingolimid
3. dimethyl fumarate
4. ocrelizumab

Answer 11

1. PML
2. bradycardia
3. decreased leucosite
4. contraindicated in hep B +

Question 12

neuromyelitis optica

Answer 12

aquaporin4 IgG

can have transverese myelitis

Question 13

ADEM- acute disseminated encephalomyelitis

Answer 13

follows immunization or infection

• demylinating of central nervous system
• acute onset and rapid progression
• multifocal neurolic deficits

Question 14

ADEM TREATMENT

Answer 14

steroids and acyclovir