MS Flashcards
Four categories of NSTI
Type 1: Polymicrobial
Type 2: Monomicrobial (beta hemolytic strep)
Type 3: gram neg (usually clostridium, also marine organisms)
Type 4: Fungal (i.e., candida)
What MRI findings may be seen with NSTI?
Thickened fascia with high signal intensity in T2 images.
What is advantage of clindamycin over penicillin for NSTI?
Clindamycin remains effective in “stationary phase”, turns off exotoxin synthesis, inhibits streptococcal M-protein synthesis (which facilitates mononuclear phagocytosis) and suppresses LPS induced monocyte synthesis of TNF.
Why are FQ contraindicated with NSTI?
May cause bacteriophage-induced lysis of S. canis, enhancing its pathogenicity.
What area is most commonly affected by HOD?
metaphysical regions of long bones.
What virus has been isolated in association with HOD?
Distemper
What muscle should be biopsied for MMM? What is the most useful test for diagnosis of this condition?
Temporalis muscle biopsy (NOT frontalis)
Serum assay for detection of muscle type 2M fiber autoantibodies
T/F the 2M antibody titer is negative with extra ocular muscle myositis?
T
What breeds are predisposed to polymyositis?
newfoundland and vizsla.
