JVECC Flashcards
Full 2016 Prevalence, clinical presentation, prognosis and outcome of 17 dogs with spinal shock and acute thoracolumbar spinal cord disease
What was prevalence of spinal shock?
Thoracic or lumbar more likely?
What was most commonly diagnosed etiology?
How was recovery?
6%
Thoracic more likely than lumbar
FCE most commonly diagnosed (7/17)
Good recovery.
Barnoon 2016 Retrospective evaluation of combined mycophenolate mofetil and prednisone treatment for MUO in dogs: 25 cases.
% response?
MST? Significance of breed?
Adverse effects of MMF?
partial or complete clinical response in 95%
MST 250 days. All pugs in study died MST 14 days
Adverse effects in 20% - GI.
Protocol enabled reduction of prednisone treatment or complete withdrawal in some cases.
McIntyre JVECC 2014 Assessment of cardiopulmonary resuscitation in 121 dogs and 30 cats at a university teaching hospital
Rate of ROSC ROSC >20 minutes Alive at 24 hours Discharged alive Most common precipitating cause What was associated with ROSC? What was associated with not achieving ROSC?
Rate of ROSC- 58%
ROSC >20 minutes - 32%
Alive at 24 hours - 10%
Discharged alive - 5%
Most common precipitating cause- CV abn.
What was associated with ROSC?
- Presence of IV catheter before CPA, presence of pulses during CPR
What was associated with not achieving ROSC?
- Increased time from CPA to CPR, longer duration of CPR, and neurologic cause of arrest
Young JVECC 2014 Decreased central venous oxygen saturation despite normalization of heart rate and blood pressure post shock resuscitation in sick dogs.
Major finding?
Decreased ScvO2 was observed in 37.8% of patients resuscitated to normal traditional perfusion parameters.
Hyperlactatemia persisted in some dogs post resuscitation (15-23%)
What are beta adrenergic effects? and what adverse effects?
Positive inotropic and chronaotropic effects within myocardium and relaxation of smooth muscle in bronchial tree and vasculature - increases splanchnic and microcirculatory perfusion.
Adverse- arrhythmias, insulin secretion, glycogenolysis, glucagon secretion, lipolysis -> increase energey requirements, lactate production, and may cause immunosuppression
What is local vasculature effect to dopamine receptor stimulation?
Inhibition of norepinephrine release from sympathetic nerve terminals -> vasodilation
Also has immunomodulatory effects (cytokine inhibition, production of anti-inflammatory mediators).
MOA vasopressin
activates V1 receptors- increases intracellular CA via phosphatidylinositol-bisphosphonate cascade.
Inhibits IL-B induced production of NO and cGMP, as well as iNOS mRNA expression
Blocks K-sensitive ATP channels in vascular endothelium which decreasing K flux and subsequently opening the voltage gated ca channels, increasing intracellular ca.
Way JVECC 2014 Determination and validation of volume to be instilled for standardized intra-abdominal pressure measurement in dogs.
What volume produced best correlation between IAP measurement and laparoscopic insufflator pressure?
What was mean IAP?
1 mL/kg
Mean - 8 cmH2O
Volume significantly affected IAP but was not affected by abdominal surgery.
Gomart Accuracy of different temperature reading techniques and associated stress response in hospitalized dogs JVECC 2014
Of rectal, auricular and axillary, which was associated with greatest stress response and which least?
What was difference in temperatures obtained?
Which of the following affected results: gender, coat length, dehydration, BCS, analgesia, age, reproductive status, operator experience?
Axillary least stressful, RT most stressful.
Rectal 38 C, Auricular 37.2, Axillary 37.
Gender and coat length significantly affected
Dehydration, BCS, analgesia, age, repro status and operator experience did not affect.
Holowaychuk JVECC 2014 Evaluation of a transcutaneous blood gas monitoring system in critically ill dogs.
Transcutaneous system consistently over estimated PaO2 and PaCO2.
Bias of 5+/- 26 for PaO2 and 9 +/- 8.5 for PCO2.
Not recommended to replace standard blood gas
Ateca JVECC 2014 Organ dysfunction and mortality risk factors in severe canine bite wound trauma.
Overall mortality?
What % had neg culture?
What factors associated with longer ICU stay?
What factors associated with mortality?
What % developed SIRS and MODS?
What was body system most commonly affected in MODS?
Overall mortality? 15%
What % had neg culture? 53%
What factors associated with longer ICU stay? Prolonged time from admission to anesthesia.
What factors associated with mortality? Prolonged anesthesia time, development of SIRS or MODS. What % developed SIRS and MODS? SIRS- 54.3% (and 24% died) MODS- 27.7% (and 67% w/ >4 organs died)
What was body system most commonly affected in MODS? Respiratory
