MS

Question 1

Demyelination in MS is T/B cell mediated?

Answer 1

T cell

Question 2

common presentation of MS

Answer 2

optic neuritis

Question 3

MLF dysfunction leads to ?

Answer 3

Internuclear ophthalmoplegia (failure of adduction&raquo_space; diplopia)

Question 4

9/10 people with MS suffer ?

Answer 4

chronic fatigue

Question 5

tx for sleepiness

Answer 5

amantadine, modafinil

Question 6

symptoms of optic neuritis

Answer 6

unilateral pain on eye movement

rapid decrease in central vision

Question 7

sensory problems common in MS

Answer 7

trigeminal neuralgia
numbness/tingling
dorsal column loss

Question 8

what is seen in CSF in MS

Answer 8

oligoclonal bands

Question 9

Are steroids given long term?

Answer 9

no
give methylprednisolone for 3 days or less in acute relapses
they dont help long term and have s/e’s

Question 10

what drugs are used to decrease relapse rates

Answer 10

Interferons
Azathioprine may be as good as INF’s and cheaper
Tecfedira - 1st line in RR

Question 11

Treatment if high disease activity despite tx with IFN

Answer 11

Tysabri (natalizuamab - Monoclonal antibody)

Lemtrada