Dementias

Question 1

Genetic RF’s for Alzheimers

Answer 1

APP gene on chr 21
presenilin genes 1 (chr 14) and 2 (chr 1)
ApopE4 allele

Question 2

What lobe is spared in Alzheimers

Answer 2

Occipital

Question 3

Rx of Alzheimers

Answer 3

Cholinesterase inhibitors - donezipil, rivastigmine

Question 4

Hallmarks of Lewy body dementia

Answer 4

Hallucinations

Fluctuating levels of attention

Question 5

Huntington’s disease = aut rec or dom?

gene?

Answer 5

aut dom

huntington gene on chr 4p

Question 6

triad of huntingtons disease

Answer 6

emotional, cognitive and motor disturbance

Question 7

which type of dementia is assoc with parkinsonian features

Answer 7

Lewy body dementia

Question 8

Day to day fluctuation

Answer 8

Lewy body dementia

Question 9

Picks disease is a type of ? dementia

Answer 9

frontotemporal

Question 10

Stepwise progression

Answer 10

Vascular dementia

Question 11

Vascular dementia:

____ infarcts seen

Answer 11

Lacunar infarcts

Question 12

pharmacological tx for mild-moderate Alzheimers

Answer 12

cholinesterase inhibitors - donepezil, rivastigmine, galantamine

Question 13

pharmacological tx for mod - severe alzheimers

what is its mode of action?

Answer 13

memantine

- blocks NMDA glutamate receptors (glutmate over action is thought to damage neurones)