MS

Question 1

patho of MS?

Answer 1

inflammation leads to demyelination of the CNS (autoimmune)

Question 2

when is the onset of MS?

Answer 2

20-30 years

Question 3

what climate is more likely to get MS?

Answer 3

temperate zones

like whaaatttt

Question 4

what gene is associated wiht MS?

Answer 4

HLA-DR

Question 5

what 3 body systems does MS fuck with?

this is a weird question but once you see the answer you’ll know what i mean

Answer 5

motor (eg weakness, numbness)
cerebellar (eg balance)
vision (eg diplopia, pain, impairment)

Question 6

in one sentence, what is the McDonald criteria?

Answer 6

must have 2+ DIFFERENT areas in the central areas of white matter affected, at DIFFERENT times

Question 7

what is the dx test of choice?

Answer 7

MRI

Question 8

what will you see on MRI?

Answer 8

lesion of cerebral or spinal plaque

demyelination with preserved axon

Question 9

what is highly suggestive of MS on a lumbar puncture?

Answer 9

oligoclonal bands

Question 10

4 types of MS?

Answer 10

RRMS (relapsing remitting)
SPMS (secondary progressive)
PPMS (primary progressive)
PRMS (progressive relapsing)

Question 11

in which type of MS do the symptoms steadily progress from the onset?

Answer 11

PPMS (10%)

Question 12

in which type of MS is there a primarily steady decline, with some remissions?

Answer 12

PRMS

Question 13

which type of MS has the initial episode months or years before the previous symptoms return?

Answer 13

RRMS

Question 14

how do you define a MS “relapse”?

Answer 14

exacerbated symptoms for more than 24h

Question 15

what is UHTHOFF’S PHENOMENON?

Answer 15

exacerbation of symptoms with increased temperatures

Question 16

which type of MS will most RRMS progress to?

Answer 16

SPMS

Question 17

how do you treat an acute attack of MS?

Answer 17

glucocorticoids

Question 18

what is the first line drug for MS?

this is different than what we learned in pharm because it was the DOC until the new drug came out

Answer 18

glatiramer

Question 19

which drug for MS relapses has a side effect of flu-like symptoms?

Answer 19

interferons

Question 20

I’m not going over the other drugs because I think they’re irrelevant

Answer 20

:)

Question 21

what is a possible cure for MS?

Answer 21

stem cell transplant

Question 22

and my 2nd glass of wine is all gone

Answer 22

goodnight