MRSA

Question 1

First line for hospital-acquired MRSA

Answer 1

Vancomycin, IV

Question 2

First-line for community-acquired MRSA (multiple)

Answer 2

Clindamycin
Sulfamethoxazole-trimethoprim (Bactrim)
Linezolid (an Oxazolidinone)
Doxycycline
Minocycline

Question 3

Vanco MOA

Answer 3

Inhibits cell wall synthesis, by binding precursors

BACTERICIDAL, concentration-dependent

Always given IV except for CDAD (little GI absorption)

Question 4

Steady State of drug acquired after:

Answer 4

Approx 4 half times, concentration dependent

Question 5

Lipoglycopeptides for ABSSSI’s

Answer 5

Oritavancin (IV)

Dalbavancin (injectable)

Question 6

Oxazolidinones - Linda and Ted for Drug Resistance (MRSA, VRE, VRSA)

Answer 6

Linezolid

Tedizolid