Aminoglycosides

Question 1

6 AminoglycoCELEBS !

Answer 1

Toby Keith
Neo Matrix
Mr. Darcy
Amy Adams
Viven Leigh (died)

Tobramycin
Neomycin
Gentamycin
Amikacin 
Streptomycin 

GRAM NEG ENTERIC

Question 2

FTANGS

Answer 2

Fofsomycin (UTI)
Tobramycin
Amikacin
Neomycin - hardest on kidneys
Gentamycin
Streptomycin - easiest on kidneys

GRAM- NEG ENTERIC

Question 3

AminoglycoCELEBS, all in their 30’s

Answer 3

• inhibits protein synthesis by binding 30s ribosomal subunits
• BACTERICIDAL, concentration dependent

Question 4

AminoglygoKINETICS

Answer 4

• Poor tissues / GI absorption&raquo_space; IM, IV, Inhale is best
• Glomerular elimination = BAD FOR KIDNEYS
• needs multiple dosing (2-3 x daily)

GRAM - ENTERIC

Question 5

Aminoglyco ADRs

Answer 5

Nephrotoxicity

• Neomycin is worst, Streptomycin is best
• tubule damage

Ototoxicity - drug accumulates in otic fluid

• Amikacin and Neomycin worst
• Vestibular and Auditory
• Dose dependent
• Can be permanent, bilateral high frequency hearing loss