Fluoroquinolones Flashcards
1
Q
Fluoro MOA
A
“No Topless Gyrating in Fluorescent Lighting”
- Inhibits topoisomerase and DNA gyrase
- rapid bacterial cell death - BACTERICIDAL
- CYP450 INHIBITION
2
Q
The Five Floxas, CO LMG, 2 generations
A
1st Gen
Cipro
Oflo
*Pseudo and gram - (minimal gram + s. aureus)
2nd Gen Levo - ONLY 2ND GEN THAT COVERS PSEUDO Moxi - best for enteric, intrabdominal Gemi * Same as 1st but now with more Gram +
3
Q
Lower Respiratory Floxas
A
Levo
Moxi
Oflo
4
Q
Patient populations not suited for Floxas
A
Kids < 16yrs (JOINT CARTILAGE INJURY)
Pregnancy category C
Renal dose adjustment
5
Q
Common minerals / OTC med that inhibit
A
Ca, Mg, Al
Antacids wait 2 hours!
6
Q
Floxas are First Line for which 4 conditions:
A
- Inpatient CAP or ICU
- Outpatient CAP w comorbidities
- Acute Pyelonephritis
- Pseudomonas
7
Q
Serious Side Effects, FDA Warning!
A
Musculoskeletal, CNS
QTC prolongation, torsades de pointes, arrhythmias
