Movement Disorders Flashcards
what is the definition of a movement disorder?
neurological syndromes in which there’s excess movement (hyperkinesia) or a paucity of voluntary/involuntary movement (hypokinesia) unrelated to weakness or spasticity
movement disorders are typically linked to what two areas of the brain?
BG and cerebellum
what is the location of the BG?
subcortical
what is the location of the cerebellum?
subcortical
what is the role of the BG? what would a lesion cause?
the role of the BG is motor control
a lesion to the BG would cause movt disorder
what is the role of the cerebellum? what would a lesion cause?
the role of the cerebellum is motor control
a lesion to the cerebellum would cause movt disorder
the BG is part of the ____ system
motor
the cerebellum is part of the ____ system
motor
does the BG have any direct connections to the SC?
nope
does the cerebellum have any direct connections to the SC?
nope again
would a unilateral lesion to the BG cause contralateral or ipsilateral symptoms?
contralateral
would a unilateral lesion to the cerebellum cause contralateral or ipsilateral symptoms?
ipsilateral
what are the BG effects on tone?
rigidity
what are the cerebellar effects on tone?
hypotonia
what are the BG effects on movt?
decreased movt: bradykinesia, hypokinesia, akinesia
what are the cerebellar effects on movt?
increased movt: ataxia, dysmetria, dysdiadochokinesia
what is the umbrella term for hypokinetic conditions that present w/tremors, bradykinesia, postural instability, rigidity?
parkinsonism
what conditions are included under the umbrella term parkinsonism?
idiopathic PD
secondary parkinsonism
atypical Parkinson’s (PD+)
what conditions fall under PD+?
MSA (multiple systems atrophy)
PSP (progressive supranuclear palsy)
CBD (corticobasal degeneration)
LBD (Lewy body dementia)
what part of the brain is impacted by PD?
the BG, specifically the substantia nigra
what does TRAP stand for?
Tremors
Rigidity
Akinesia
Postural instability
how is PD often diagnosed?
through observation and response to Levodopa
what is the most common med to treat PD?
Sinemet (carbadopa/Levodopa)
what are the 3 motor loop pathways required for normal functioning?
hyperdirect (stop) pathway
“go” pathway
“no-go” pathway