Motor Units, Muscle Spindles, Golgi Tendon Organs and Joint Receptors Flashcards

1
Q

the somatic motor system is responsible for what type of skeletal muscle movement?

A

voluntary movement (and involuntary spinal reflexes)

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2
Q

what two neurones make up the somatic motor system?

A

upper motor neurones (UMNs) within brain

lower motor neurones (LMNs) within brainstem and ventral horn of spinal cord

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3
Q

what is the main function of UMNs in relation to LMNs?

A

UMNs modulate the activity LMNs

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4
Q

LMNs receive input from UMNs and what other places?

A

proprioceptors and interneurones

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5
Q

LMNs command the “final common pathway” - what is the function of this?

A

to cause muscle contraction

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6
Q

what two types of muscle fibres are found in LMNs - one supplies the bulk of muscle whilst the other supplies the muscle spindle?

A

alpha (a) motor neurones (a-MNs) supply muscle bulk

gamma (y) motor neurones (y-MNs) supply spindle

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7
Q

what is meant by synergistic muscles such as the biceps brachii and brachioradialis?

A

they both aim to complete the same movement (ie arm flexion)

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8
Q

what name is given to muscles which oppose each others action?

A

antagonist eg tricep is an antagonist of biceps brachii

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9
Q

what is the difference between axial and distal muscles?

A

axial muscles control movements of the trunk (posture)

distal muscles move the hands, feet and digits (allowing fine manipulation of objects by the hand)

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10
Q

why are the ventral horns of the spinal cord larger at the cervical (C3-T1) and lumbar (L1-S3) enlargements?

A

more alpha motor neurones are found here for relay of motor info to upper and lower limbs

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11
Q

what is encompassed in a motor unit?

A

α-MN and all of the skeletal muscle fibres that it innervates

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12
Q

what name is given to all of the alpha motor neurones innervating one muscle?

A

motor neurone pool

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13
Q

what does each AP cause in a muscle fibre?

A

a muscle twitch

summation of twitches causes a sustained contraction

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14
Q

describe the somatotopic map of the ventral horn of the spinal cord?

A

axial muscles = medial
distal muscles = lateral
flexor muscles = more dorsal in ventral horn
extensor muscles = anterior of ventral horn

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15
Q

what 3 neurones can input to an alpha-motor neurone?

A

dorsal root ganglion cells
upper motor neurones
spinal interneurones

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16
Q

activation of muscle fibres depends on what?

A

firing rates of LMNs
number of LMNs that are all active
co-ordination of movement (agonist vs antagonist)

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17
Q

force production by innervated muscles depends on what?

A
muscle fibre size (hypertrophy)
fibre phenotype (fast/slow)
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18
Q

if the AP frequency is low, why does no prolonged contraction occur?

A

enough time is given for the muscle to relax

“relaxation phase” involved calcium reuptake into the SR and the reversal of toponin cross-bridges

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19
Q

give an example of muscles in the body which require small motor units to carry out their function?

A

extraocular eye muscles as fine movements are required

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20
Q

give an example of muscles in the body requiring large motor units to carry out their function?

A

large postural (antigravity) muscles eg leg muscles

21
Q

motor units only contain fibres of one type ie fast or slow - true or false?

A

true - slow and fast twitch fibres are interspersed throughout a full muscle but are specific in each individual motor unit

22
Q

each muscle fibre is innervated by a single motor axon at endplate (neuromuscular junction) - where along the fibre are these found?

A

midway along the fibre, usually in the centre

23
Q

why are the muscle fibres divided into slow and fast twitch types?

A

they differ in how quickly myosin ATPase splits ATP to provide energy for cross bridges

24
Q

what are the main types of slow and fast twitch muscle fibres?

A

slow oxidative (type I)

fast (IIa, IIb, IIx)

25
Q

what makes a muscle fibre slow type I?

A

get ATP oxidative phosphorylation
slow contraction and relaxation
fatigue resistant
red fibres as high myoglobin content

26
Q

what is the difference between fast twitch type II muscle fibres?

A

IIa - ATP from oxidative phosphorylation

  • fast contraction and relaxation
  • resistant to fatigue
  • well vascularised = relatively red in colour

IIb, IIx - ATP from glycolysis

  • fast contraction
  • not fatigue resistant
  • white in colour
27
Q

what is the henneman size principle?

A

the susceptibility of an α-MN to discharge AP is a function of its size

smaller α-NM units (part of slow motor units) have lower threshold - are recruited first

then larger ones recruited

LMNs are recruited in an order appropriate to the physical task that is being performed

28
Q

describe the recruitment of LMNs from standing to running?

A

standing - slow type I
walking - fast type IIa
run - fast type IIx (IIb doesnt exist in many mammals including humans)

29
Q

describe the myotatic reflex?

A

when a muscle is stretched, it pulls back (eg knee jerk response from quads)

30
Q

what structure is responsible for the myotatic reflex?

A

muscle spindle (sensory organ)

this is stretched with the muscle as it is parallel to the fibres

31
Q

what is found inside the muscle spindle?

A

fibrous capsule
intrafusal muscle fibres
sensory afferents (very fast conducting)
gamma motor neurone efferents

32
Q

describe how the myotonic reflex is initiated?

A
stretch of muscle spindle 
activation of Ia afferent 
excitatory synaptic transmission in spinal cord (monosynaptic)
activation of α-MN
contraction of homonymous muscle
33
Q

what mediates the excitatory synaptic transmission in spinal cord?

A

glutamate

34
Q

what manoeuvre can be attempted if a spinal reflex is deemed to be absent?

A

jendrassik manoeuvre

  • patient interlocks fingers and tried to pull hands apart strongly when instructed
  • reflex is usually exaggerated
35
Q

what spinal levels are tested in the biceps, supinator, triceps, knee and ankle jerks?

A
biceps C5/6
supinator C5/6
triceps C7
knee L3/4
ankle S1
36
Q

why are α and γ-MNs normally co-activated to make the intrafusal muscle fibres in the muscle spindle contract in parallel with the extrafusal fibres?

A

to prevent the intrafusal muscle spindle fibres getting slack and not firing any APs

37
Q

what different named fibres are found in muscle spindle?

A

nuclear bag fibres: bag 1 (or dynamic) and bad 2 (or static)

chain fibres

38
Q

what sensory afferents wrap around the intrafusal fibres in the muscle spindle?

A

IIa afferents - wind around the centre of all intrafusal fibres

II fibres - wrap around endings on all intrafusal fibres except the bag 1 dynamic type

39
Q

when are dynamic and static muscle fibres activated respectively?

A

dynamic y-NMs are active when muscle length changes rapidly and unpredictably

static - active when muscle length changes slowly and predictably only static y-MNs are active

40
Q

where are golgi tendon organs found and what are they involved in?

A

found at junction of muscle and tendon

involved in inverse myotatic reflex

41
Q

golgi tendon organs lie in series with muscle fibres rather than in parallel - true or false?

A

true

42
Q

what is the function of the golgi tendon organs and the inverse myotatic reflex?

A

regulate muscle tension - protect muscle from overload

43
Q

describe the neurone pathway in the reverse myotatic reflex?

A

group IIb afferent (not IIa like normal myotatic) enter spinal cord
synapse upon inhibitory interneurones
these synapse upon the alpha motor neurones of the muscle to prevent contraction

44
Q

what types of nerve endings contribute to proprioception and where are they found?

A
free nerve endings (in capsule and CT - nociceptive)
golgi type endings (found only in ligaments - protective)
paciniform endings (found in periosteum - acceleration detectors) 
ruffini endings (found mainly in joint capsule - static position and speed of movements)
45
Q

where does proprioception information arise from?

A

muscle spindles
golgi tendon organs
joint receptors

46
Q

a loss of proprioception leads to what type of movement?

A

vision guided movement ie must look at limb before moving it or must focus on an object in distance to sit/stand without falling over

47
Q

what is meant by reciprocal inhibition?

A

the antagonist of a muscle must relax for the other to perform its function eg for biceps to contract and flex the arm, the triceps must relax

48
Q

excitatory interneurones mediate the flexor reflex and the crossed extensor reflex - explain how these occur is a patient were to stand on a damaging stimulus such as drawing pin?

A

sensory afferents detect damage
neuron sent back to spinal cord which diverges into 4 pathways
1 excitatory pathway to flexor muscle and 1 inhibitory pathway to extensor muscle on affected side

1 excitatory pathway to extensor and inhibitory to flexor on opposite side (to provide stability whilst affected leg flexes upwards)