Motor System Disorders Flashcards
What is the basal ganglia composed of?
Substantia nigra pars compacta (SNc)
Striatum
Globus Pallidus
Subthalamic nucleus
What does the substantia nigra produce?
It is a source of dopamine in the midbrain
Where is the caudate nucleus?
It is C shaped and it lines the lateral ventricle.
What makes up the striatum?
Caudate and putamen.
This receives input from the SNc and cortex.
What makes makes up the lentiform nucleus?
Putamen and globus pallidus
They are anatomically but not functionally related.
How does the basal ganglia communicate with the motor cortex?
Via the thalamus.
Increased thalamic activity causes increases cortical activity and visa versa.
What is the normal function of the basal ganglia?
Unclear!
Probable role in reinforcing appropriate movements and removing inappropriate movements.
Direct pathway = reinforce appropriate movements (excitatory).
Indirect pathway = edit out inappropriate movements (inhibitory).
What does dopamine do?
Dopamine facilitates movement by exciting the motor cortex. (excites direct pathway by stimulating excitatory D1 receptors on stratal neurones taking part in the direct pathway, inhibits indirect pathway by activating inhibitory D2 receptors on stratal neurones taking part in the indirect pathway.)
Do the basal ganglia regulate the ipsilateral or contralateral side?
Ipsilateral motor cortex, so if the SNc os affected unilaterally (rate) there will becontralateral signs due to decussation of the corticospinal tract.
What causes the Parkinsonian symptoms?
Caused by degeneration of dopaminergic neurones in SNc.
Therefore, have alsot the dopamine-driven facilitation of movement via both pathways.
What are the signs and symptoms of Parkinsons?
Tremor
Rigidity
Bradykinesia
Hypophonia
Decreased facial movements / mask like facies
Micrographia (small handwriting)
Dementia
Depression
What is the inheritance pattern of Huntington’s?
Autosomal dominant
When does Huntingtons usually start showing symptoms?
Early onset around 30-50 years old
What is the early stages of Huntington’s associated with?
Early stages of Huntington’s is associated with loss of inhibitory projections from striatum to GPe.
This leads to hyperkinetic features (increased movements as the brakes have been taken off the thalamus)
What are the features of Huntington’s?
Chorea (dance-like movements due to increased motor cortex activation)
Dystonia (uncomfortable contractions of agonists and antagonists simultaneously leading to odd postures caused by over activity in agonist/antagonist muscle circuits and loss of co-ordination between these)
Loss of co-ordination
Cognitive decline and behavioural disturbances (related to role of basal ganglia in higher metabolic functions)