Mood Disorders Flashcards

1
Q

What are the features of depressive disorders?

A

Patient usually have the symptoms continually for 2 weeks and consist of:

Low mood
Lack of energy
Lack of enjoyment and interest (anhedonia)

They must have at least 2 of these three symptoms.

Can go from mild (still at work) to severe (psychotic) - If severe, can be too depressed too not bothered to kill themselves. Sometimes patients could die because they don’t eat / drink

Depressive thoughts
Biological symptoms - lack of appetite, sleep, concentration, libido
Psychotic symptoms

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2
Q

What is an adjustment reaction?

A

Symptoms develop sudden afte an ‘event’

Symptoms fluctuate

Time limited

Preoccupation with ‘event’

Energy not low

No particular pattern to sleep disturbance

Reduced increased appetite

Feelings of anger and frustration more typical.

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3
Q

How is depression different to adjustment?

A

Symptoms develop gradually.

Symptoms continuous

Usually at least 2 weeks.

Lack of interest

Low energy

Sleep disturbance with typically EMW

Loss of appetite and weight loss are typical.

Low self esteem and feelings of guilt and blame are typical.

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4
Q

How can our personality be a cause for depressive symptoms?

A

Our personality is defined by:

How we get on with people, ability to make relationships.

Extrovert or introvert

How empathetic we are

How anxious and nervous we are; or how confident

How we can make plans and stick to these plans

How we respond in stressful circumstances

Our overriding mood.

Some people have a sense of not being happy within themselves, sometimes related to a feeling of emptiness. This does not necessarily mean that they are depressed.

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5
Q

What is the difference between mania and hypomania?

A

Hypomania - at home

Mania - At psychiatric hospital

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6
Q

What are the symptoms of mania / hypomania?

A
Elevated mood
Increased energy
Pressure of speech
Reduced sleep
Flight of ideas
Normal inhibitions lost - dangerous
Attention cannot to sustained
Self esteem is inflated, often grandiose 
May have psychotic symptoms 

Only require these symptoms for a week

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7
Q

What is bipolar disorder?

A

A diagnosis made following 2 episodes of a mood disorder at least one of which is mania or hypomania.

Therefore, you dont ever have to have a diagnosis of depression to be given the diagnosis of bipolar disorder

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8
Q

What are the two different types of bipolar?

A

Type 1 - episodes of mania

Type 2 - No mania, only hypomania (no psychotic symptoms)

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9
Q

What physical disorders could cause mood disorders?

A
Hormone disturbance such thyroid dysfunction 
Vitamin deficiencies such as vitamin B12
Heart and lung diseases
Blood vessels not functioning well
Kidney disease
Liver disease
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10
Q

How do alcohol and drugs affect mood?

A

People drinking too much over a period is well known cause of developing depressive symptoms. -Only drink when happy.

A number of recreational drugs cause depressive symptoms, especially drugs that initially induce a feeling happiness and well beoing such as ecstasy or amphetamines.

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11
Q

What brain structures are involved in mood disorders?

A

Limbic system
Frontal lobe
Basal ganglia

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12
Q

What are the main functions of the limbic system?

A

Emotion
Motivation
Memory

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13
Q

What are the functions of the frontal lobes?

A
Motor function
Language 
Executive functions 
Attention 
Memory 
Mood 
Social and moral reasoning
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14
Q

What are the functions of the basal ganglia?

A

Emotion
Cognition
Behaviour

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15
Q

What neurotransmitters are involved in psychotic (particularly depressive) disorders?

A

The two main neurotransmitters for depressive disorders are:
Noradrenaline
Serotonin

Other neurotransmitters important in psychiatric conditions include:
Dopamine (mania nd psychosis)
Acetylcholine
GABA
Glutamate
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16
Q

When antidepressants not used?

A

Mild depression - no evidence

Bipolar disorder - Not work as can make mania worse (if use, make it controlled)

17
Q

What drugs can be used to treat depression?

A
Antidepressants:
SNRI’s - best 
TCA - Work on all receptors so bad side effects
NARI's 
SSRIs - normal course of treatment 
MAOI

Reserpine - not work. It depletes the nerve endings of noradrenaline

18
Q

What does serotonin do in the brain?

A

Sleep
Impulse control
Appetite
Mood

Produced in the brainstem and transported to cortical areas in limbic system

19
Q

How is serotonin implicated in depression?

A

5HIAA (a serotonin metabolite) depletion in CS in people with depression
Tryptophan (5HT precursor) depletion causes depression

Shown in PET and SPET studies.

20
Q

What causes people to become clinically depressed?

A

There are many different causes that can be categorised as follows:

Predisposing: genetics, childhood experiences, female gender

Perpetuating (maintaining factors): stressful job, studies, relationship difficulties, substance misuse, financial strain, housing, unemployment

Precipitating factors: Life events often related to losses such as loss of someone you love, los of health and breakup of relationships.

21
Q

Describe the epidemiology for depression?

A

1 in 20 people suffer with an episode of depression each each.

Peak onset = 30s/40s

One of the leading cause of disability worldwide.

22
Q

Despite the epidemiology of mania

A

Lifetime risk 1-3%

Mean age of onset is 19

Male:Female 1:1

Monozygotic twin show a 40-70% concordance rate.

23
Q

What factors predispose to depression?

A

Genetics
Childhood experiences
Family gender

24
Q

How do we know genes cause depresssion?

A
Family studies
Twin studies
Adoptee studies
Linkage studies
Association 

It is thought that about 50% of the vulnerability to become depressed is genetically determent.

25
Q

How do childhood experiences cause depression?

A

Quality of attachment
Quality of parental relationships
Loss of a parent
Bullying

Causation is cumulative

26
Q

Why are women more likely to get depression than men?

A

Multifactorial

Social and occupational role:

  • Marriage is protective for a man but not for a woman
  • Childcare is stressful and often falls to the women
  • Number of depressive episodes relates to the number of children.

Men are more likely to distract themselves from depressed mood (less ruminations)

Women are more willing than men to admit to being depressed.

27
Q

Give examples of social stressors that can be a cause of depression

A

Social economic status
unemployment
Financial hardship
Isolation from family and friends

28
Q

What are the different forms of treatment?

A

Medication: direct effect on the biochemistry of the brain

Social and psychological intervention such as CBT: Have a measurable effect on the biochemistry of the brain.

29
Q

What is amitriptyline?

A

TCA - dangerous and can kill you if overdose

But, it works so, generally used as second line after SSRIs.

30
Q

What medications can be used for depression?

A

Antidepressants:
SSRIs - sertraline, citalopram, fluoxetine
SNRIs - Venlafaxine, duloxetine
TCAs - round since 1950s, lots of side effects as broad action

Also mood stabilisers - Lithium, Sodium Valproate

Antipsychotics - Quetiapine

ECT

31
Q

Antidepressants for how long after better?

A

One episode of depression - 6 months -1 year
Two episodes - 1-2years
3 episodes / severe in hospital - 5 years - lifetime

32
Q

How do you treat bipolar?

A

NOT ANTIDEPRESSANTS

Use mood stabilisers - Lithium, Sodium Valproate, Carbamazepine, Lamotrigine

Use antipsychotics e.g. Quetiaine, Aripiprazole, Olanzapine

33
Q

What are the receptors for noradrenaline?

A

4 types: a 1 and 2 and B 1 and 2
The function of B receptors isn’t clear.
a receptors play a role in arousal and mood.