Motility - Sheet1 Flashcards
normally all sphincters are closed except
pyloric
when does mmc start
90-120 minutes after eating
saan walang mmc
esophagus and colon
mmc is initiated by? what acts like this?
motilin (secreted by stomach by vagal stimulation); erythromycin
phases of mmc
quiescent (longest), irregular contractions, luminal contractions
fed pattern vs mmc
fed: lower amplitutde of contractions; longer and continuous
time of transport: longest? shortest? significance?
longest in colon, shortest in esophagus. high chance of malignancy in colon
abdominal, thoracic pressure? tendency?
ab: +55, thoracic: -5; chyme should go up but prevented by esophageal sphincters
ues muscle; resting pressure; increased and decreased by?
cricopharyngeus; 50-150 mmHg; inc by respiration, distention, stress; dec by sleep and anesthesia
control of UES vs LES
UES - nervous; LES - nervous and hormonal
ues vs les vs stomach resting pressure
50-150 mmHg; 15-150 mmHg; 7-50 mmHg
stimulus of LES opening
esophageal peristalsis
LES control
nervous - vagus; hormonal - VIP, NO
NO mechanism
stimulates release of VIP -> cAMP & NO
effect on LES motility: gastrin, motilin
inc
effect on LES motility: CCK, estrogen, progesterone, secretin
dec
effect on LES motility: bombesin, enkephalin
inc
effect on LES motility: VIP, GIP
dec
effect on LES motility: antacids
inc
effect on LES motility: barbiturates (antidepressant), Ca blockers (hypertension), anticholinergics, theophylline (asthma, COPD)
dec