Hepatic Physiology - Sheet1 Flashcards
how long for portal vein blood to reach sinusoids
44 secs
tests for acute liver failure
FBG, clotting factors
liver failure, patient can die due to?
excessive bleeding, hypoglycemia
what enzyme impt for biochemical detoxification in liver
cytochrome P450
bilirubin bound to _ is transported into hepatocyte through the _
Alb-B, OATP
conjugated with _ through the action of (enzyme). significance?
glucoronic acid; glucoronyl transferase; water-soluble, easier transport
conjugates secreted into bile via _
MRP2
jaundice if total plasma bilirubin is how much
> 2 MG/DL
causes of jaundice (5)
inc prod bilirubin, dec uptake of bilirubin in hepatocytes, dec binding (high unconjugated);;; dec secretion, bile duct obstruction (high conjugated)
what causes hepatic encelopathy
ammonia not converted to urea (inc ammonia in blood); clinical signs - headache, confusion, sleeping, coma
most significant ptn (quantitatively) synthesized by the liver
albumin
accounts for majority of plasma oncotic pressure
albumin
ptns whose plasma concen inc or dec significantly following inflammation
acute phase ptns (C-reactive ptn, fibrinogen, plasminogen)
low albumin and clotting factors may cause (2)
edema and ascites
65% dry wt of bile
BILE ACIDS
