Motility Flashcards
Most effective treatment for rumination syndrome?
Diaphragmatic breathing
Rectoanal inhibitory reflex (RAIR) would be abnormal in patients with This disease?
Hirschsprung’s disease.
Diffuse esophageal spasm is characterized by increased spastic contractions, defined by?
a short distal latency (under 4.5 sec)
Hypercontractile esophagus is characterized by this manometric measurement
DCI > 8000 mmHgscm
Linaclotide vs lubiprostone -MoA?
How to pick?
agonist at the guanylate cyclase–C (GC–C) receptor vs intestinal chloride channel secretion
Avoid lubiprostone in nauseous patients

chronic intestinal pseudo-obstruction - etiologies?
Neuropathic - Diabetes mellitus, paraneoplastic syndrome (carcinoid tumor), neurofibromatosis, and multiple sclerosis
Myopathic - systemic sclerosis
underlying pathophysiology of achalasia?
1) degeneration of ganglionic cells in the myenteric plexus of the distal esophagus resulting in the preferential loss of inhibitory innervation
2) decreased release of nitric oxide and vasoactive intestinal peptide, the neurotransmitters providing inhibitory input
Neurotransmitters that increase esophageal and LES contractility? Decrease esophageal and LES contractility?
Acetylcholine and substance P
nitric oxide and VIP
Decreased distal latency in 60 percent of test swallows
Diagnosis?
Diffuse esophageal spam
What relaxes the internal anal sphincter?
1) bearing down
2) rectal distention
Medication for dumping syndrome?
Octreotide
ARM - What measurement evaluates internal anal sphincter? External anal sphincter?
anal sphincter resting pressure
anal sphincter squeeze pressure
Ileal brake triggered by?
Fat in ileum
Gastric electrical stimulation has been shown to work in this subset of Gastroparesis patients?
diabetic gastroparesis
gastric emptying of solids should not be done in diabetic patients with blood glucose greater than?
275
