Morphine drug sheet

Question 1

What is the presentation or morphine

Answer 1

10mg in 1 mL glass tubule

Question 2

What is the pharmacology of morphine

Answer 2

opioid analgesic

Question 3

What are the CNS effects of morphine

Answer 3

1. CNS depression (leading to analgesia)
2. Respiratory depression
3. Depression of cough reflex
4. Stimulation - euphoria, nausea, vomiting, pin point pupils, dysphoria
5. Dependence

Question 4

What are the CV effects of morphine

Answer 4

1. Vasodilation

2. Decreases conduction velocity of the AV node

Question 5

What are the primary emergency indications for morphine

Answer 5

1. Pain relief
2. LVF w/ SOB and full field crackles
3. Sedation to enable and maintain intubation
4. RSI

Question 6

What are the primary contraindications for morphine

Answer 6

1. History of renal failure/impairment
2. Hypersensitivity
3. Late 2nd stage labour

Question 7

What are the primary precautions for morphine

Answer 7

1. Elderly/frail
2. Hypotension
3. Respiratory depression
4. Current asthma
5. Respiratory tract burns
6. Known addiction
7. Acute alcoholism
8. Monoamine oxidase inhibitors

Question 8

Onset, peak and duration of morphine

Answer 8

IV:
Onset = 2-5 minutes
Peak = 10 minutes
Duration = 1-2 hours

IM:
Onset = 10 - 30 mins
Peak = 30-60 mins
duration 1- 2 hours

Question 9

What are the side effects of morphine

Answer 9

CNS:

• Drowsiness
• Respiratory depression
• Euphoria
• Nausea, vomiting
• Addiction
• Pin point pupils

CV:

• Hypotension
• Bradycardia