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triptans contraindications + SE
contraindication - ischaemic heart disease cerebrovascular disease
SE
- tightness throat + chest
- tingling, heaviness
subarachnoid haemorrhage complications
rebleed - in first 12hrs
hydrocephalus
vasospasm - 7-14days after onset
SIADH - hyponatraemia
seizures
mononeuritis multiplex
simultaneous/sequential involvement of individual non-contiguous nerves
- patern of involvement asymmetrical
- loss of sensory + motor function of multiple non-contagious nerves
seizures and driving
1st/isolated seizure/no structural abnormalities/EEG findings -> 6months
established epilepsy -> 12months seizure free
stroke/TIA + driving
stroke - 1 month off driving
multiple TIAs over short period of time - 3months + onform DVLA
neuropathic pain mx
amitriptyline
duloxetine
gabapentin
(if one doesnt work try another)
types of bipolar
1 - one episode of mania
2 - depression with hypomania
hypomania vs mania
mania >=7days
hypomania - 4days of less severe symptoms which dont impact on fucntioning
serotonin syndrome
excess serotonin in synaptic cleft - most often caused by taking a combo of SSRI + MAOI (left of meds they take both)
triad
1. neuromuscular excitation - hyperflexia, clonus, myoclonus
2. altered mental status - delirium agitation, insomnia
3. autonomic dysregulation - tachycardia, increase temp
**prolonged fever - rhabdo, metabolic acidosis, renal failure
what part of the brain does addiction act on
mesolimibic pathway to mediate pleasure (positive reinforcement)
- overstimulation, decrease in dopamine receptor expression
wernickes vs korsakoffs
wernickes
- acute thiamine def.
- ataxia, nystagmus, confusion
korsakoffs
- chronic thiamine def
- dementia
what antidepressants are excreted in breast milk
all of them !
- SSRIs + tricyclics show decreases levels
– **except fluoxetine
can still give just monitor baby
landmark fr pudendal nerve bloack
ischial tuberosity
when would you give duloxetine in urinary incontinence
stress incontinence who dont respond to pelvic floor exercises + decline surgery
chorioamnitis presentation
uterine tenderness
foul smellling discharge
fetal tachycardia
(UTI/STI would have hx of dysuria)