Mood stabilizers Flashcards
Tx of lithium toxicity
Fluid resuscitation Dialysis if [Li] > 4.0
SJS
Lamotrigine
Therapeutic level of valproate
6-12
Agranulocytosis
Carbamazepine
Increases or decreases [Li]: Dehydration
Increases
Skin rash
Carbamazepine
Hyponatremia
Carbamazepine
Monitor in patients on Li:
TFTs GFR/kidney function Blood levels of Li
Symptoms of lithium toxicity
Fine tremor AMS Convulsions
Low platelets
Valproic acid
Lethal range of Li
>2.0
Good for mixed episodes and rapid cycling
Carbamazepine Valproic acid
Neural tube defects
Carbamazepine, valproic acid
Tx for bipolar preggo
Clonazepam
Increases or decreases [Li]: Impaired renal function
Increases
Aplastic anemia
Carbamazepine
Increases or decreases [Li]: NSAIDs
Decreases
Good for trigeminal neuralgia
Carbamazepine
Toxic range of Li
>1.5
6 factors affecting lithium levels
NSAIDs (decrease [Li]) ASA Dehydration (increases [Li]) Salt deprivation (increases [Li]) Impaired renal function (increases [Li]) Diuretics
Increases or decreases [Li]: Salt deprivation
Increases
Therapeutic level of carbamazepine
60-120
EKG findings with lithium toxicity
T wave flattening or inversion + U waves
Therapeutic range of Li
0.6-1.2
Hemorrhagic pancreatitis
Valproic acid
LFTs needed
Carbamazepine, valproic acid
CI to lithium
Severe renal disease Pregnancy/breastfeeding Diuretics Digoxin MI Myasthenia gravis
MC SE of carbamazepine
Rash