Antidepressants Flashcards
Treatment of enuresis
TCAs
TCA with least sedating effects
Desipramine
CI in hypertensives
Venlafaxine
Good for depression with insomnia
Trazadone
Weight gain
Mirtazapine
Treatment of hypertensive crisis with MAOI
Phentolamine
Useful for refractory depression
Venlafaxine Trazadone/nefazodone Mirtazapine
ADs with highest risk for serotonin syndrome
Sertraline and fluvoxamine
TCA that’s most serotonin specific
Clomipramine
SSRI with highest risk of GI upset
Sertraline
AD with least sexual side effects
Bupropion
TCA with least orthostatic hypotension
Nortryptiline
SSRI only approved for OCD
Fluvoxamine
MOA TCAs
Inhibit reputable of NE and 5HT
AD that causes withdrawal
Venlafaxine Can occur after missing 1-3 doses (Flu like symptoms, electric-like shocks or zaps)
Don’t take with St. John’s wart
Venlafaxine
SSRI with no need to taper
Fluoxetine
Good for depression in underweight people
Mirtazapine
Caveat of mirtazapine for sedation
Sedating at 15 mg or less Above 15 mg it increases NE and is less sedating
SARI
Trazadone and nefazodone (serotonin antagonist and reuptake inhibitor)
AD that can exacerbate psychosis
Bupropion (Dopaminergic effects)
AD you can’t give to an anorexic/bulimic pt
Bupropion
SSRI with stimulant properties
Paroxetine
Priapism
Trazadone
AD with fewest drug-drug interactions
Citalopram
AD with sedation as major SE
Trazadone and nefazodone
AD you can’t give to pt with seizures
Bupropion
Agranulocytosis
Mirtazapine
SNRI
Venlafaxine (why you can’t give it to hypertensive patients)
CI to bupropion
Seizures and active eating disorders MAOI use
NASA
Mirtazapine (NE and 5HT antagonist)
CI to TCAs
Conduction abnormalities
SSRI with most serotonin specificity
Paroxetine
Pt stops taking AD and develops body aches, fever, N/V
Venlafaxine withdrawal
TCA with least anticholinergic effects
Desipramine
SSRI with longest half life
Fluoxetine
AD with most drug-drug interactions
Paroxetine
Pt on phenelzine with persistent depression. Which ADs can you not give?
SSRI or bupropion
Pt stops taking AD and complains of shock-like pains
Venlafaxine withdrawal
NDRI
Buproprion (remember dopamine = worsened psychosis)