Anxiolytics/Hypnotics

Question 1

Benzo good for insomnia

Answer 1

Flurazepam, temazepam, triazolam

Question 2

Long-acting benzos

Answer 2

Chlordiazepoxide Diazepam Flurazepam

Question 2

Benzos that are ok in liver disease

Answer 2

Lorazepam Oxazepam Triazolam

Question 3

CI to benzos

Answer 3

COPD, addiction, restrictive lung disease

Question 4

MOA of benzos vs. barbs

Answer 4

Benzos = increase FREQUENCY of GABA channel opening Barbs = increase DURATION of GABA channel opening + act as direct GABA agonists at high doses

Question 5

MOA of buspirone

Answer 5

Partial agonist at 5HT1a

Question 6

Disadvantage of buspirone

Answer 6

Slower onset of action vs benzos (1-2 weeks)

Question 7

Intermediate-acting benzos

Answer 7

Lorazepam Alprazolam Clonazepam Temazepam

Question 8

Anxiolytic that is nonsedating

Answer 8

Buspirone

Question 10

Tx of anxiety in alcoholic

Answer 10

Buspirone (doesn’t potentiate CNS depression of EtOH)

Question 11

Short-acting benzos

Answer 11

Oxazepam Triazolam

Question 12

Benzo with rapid onset

Answer 12

Diazepam, triazolam

Question 13

Causes seizures with abrupt withdrawal

Answer 13

Alprazolam