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Antipsychotics Flashcards

1
Q

Atypical antipsychotics

A

Aripipazole Risperidone Clozapine Olanzapine Quetiapine Ziprasidone

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2
Q

Retinal pigmentation

A

Thioridazine

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3
Q

Treatment for tardive dyskinesia?

A

Stop drug! Switch to atypical. Cholinomimetic, benzos, or beta blockers short term

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3
Q

Monitor LFTs

A

Olanzapine

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4
Q

Decanoate forms available

A

Haloperidol Fluphenazine

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4
Q

Atypical with highest risk for EPS

A

Risperidone

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5
Q

Atypical vs. typical: Better for positive symptoms

A

Same efficacy

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6
Q

Eye exams needed

A

Quetiapine, chlorpromazine (cataracts, corneal/lens deposition)

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7
Q

QTc prolongation

A

Ziprasidone, thioridazine

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8
Q

EPS > 6 months

A

Parkinsonsim

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9
Q

Blue-gray skin discoloration

A

Chlorpromazine

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9
Q

Highest incidence of akathesia

A

Aripiprazole

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10
Q

High-potency typicals

A

Haloperidol Trifluoperazine Fluphenazine Perphenazine Pimozide

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11
Q

Tx acute dystonia

A

Benadryl, benztropine

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12
Q

Weight neutral

A

Aripriprazole Ziprasidone

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13
Q

Tx parkinsonism

A

Benztropine, amantadine, bromocriptine

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14
Q

What causes tardive dyskinesia?

A

Increase in number of DA receptors in response to AP results in less ACh

15
Q

EPS < 12 hours

A

Acute dystonia

16
Q

Side effects more common with high potency antipsychotics

A

EPS (Parkinsonism, dystonia, akathisia) Tardive dyskinesia NMS

17
Q

Tx akasthesia

A

Propanolol (first line) Benzo

19
Q

Dopamine antagonizes which two substances?

A

ACh and prolactin

20
Q

Low-potency traditonals

A

Chlorpromazine Thioridazine

20
Q

Patients at highest risk for NMS?

A

Males who just began taking med

22
Q

Atypical vs typical: Better with negative symptoms

24
Q

Least weight gain of atypicals

A

Quetiapine

24
Q

Atypical with highest risk for hyperprolactinemia

A

Risperidone

25
Q

Orthostasis

A

Quetiapine

26
Q

MOA: atypical vs typical antipsychotics

A

Typical- D2 antagonism Atypical- D2 and 5HT2 antagonism

26
Q

EPS 30-90 days

A

Akasthesia

27
Q

When does tardive dyskinesia begin?

A

> 6 months after starting med

28
Q

Need weekly blood draws

A

Clozapine (agranulocytosis)

30
Q

Seizures

A

Clozapine Low potency typicals (chlorpromazine and thioridazine) are more likely than high potency

31
Q

Patients at highest risk for tardive dyskinesia

A

Older women on Rx > 6 months

33
Q

Typical antipsychotics

A

Haloperidol Chlorpromazine Thioridazine Trifluoperazine

34
Q

Lens and corneal deposits

A

Chlorpromazine

36
Q

Most common side effect of olanzapine

37
Q

EPS > years

A

Tardive dyskinesia

38
Q

Treatment of EPS?

A

Benztropine (anticholinergic), amantadine (flu Rx, M2 inhibitor), or benzos

39
Q

What is the cause of sexual dysfunction seen with some ADs and APs?

A

Alpha blockade

40
Q

Agranulocytosis

A

Clozapine (or mirtazapine if AD)

Psych Meds (5 decks)

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