Mood Stabilisers Flashcards
1
Q
Lithium side effects
A
GI upset Fine tremor Polyuria Polydipsia Metallic taste Weight gain Oedema Hypothyroidism Impaired renal function Leucocytosis Teratogenic
2
Q
Lithium toxicity mild signs
A
Nausea Vomiting Apathy Coarse tremor Ataxia Muscle weakness
3
Q
Lithium toxicity signs severe
A
Nystagmus Dysarthria Impaired consciousness Hyper reflexia Oliguria Hypotension Convulsion Coma
4
Q
Lithium monitoring
A
Lithium level- 3m
U and E’s- 6m
TFT’s FBC’s- 12m
Every week for 1st 4 weeks then -
5
Q
Valproate mechanism and indications
A
May act via GABA
- acute mania/hypo mania
- prophylaxis of bipolar
6
Q
Valproate side effects
A
Increased appetite and wt gain Sedation and dizziness Ankle swelling Hair loss N + V Tremor Haematological abnormalities Increased liver enzymes Teratogenic
7
Q
Lamotrigene indications
A
Bipolar depression (Prophylaxis) Augmentation of antidepressants Clozapine augmentation Least teratogenic
8
Q
Lamotrigene side effects
A
N + v Rashes Headache Aggression/irritability Sedation and dizziness Tremor
9
Q
Carbamazepine mechanism of action and indications
A
Blocks voltage gated dependent NA+ channels
- acute mania/hypermania
- prophylaxis
- bipolar depression
- antidepressants augmentation
10
Q
Lithium mechanism of action and indications
A
Mechanism is unclear
- acute mania/hypo mania
- prophylaxis of bipolar
- treatment resistant depression
