Mood stabilisers Flashcards
Lithium indication
acute mania
bipolar maintainance
Thyroid side effects of lithium
goitre
hypothyroidism
autoimmune thyroiditis
hyperthyroidism
Lithium dosage issues
- Narrow therapeutic index
- cleared by kidney so concentration is based on fluid status
Most common Lithium side effects
tremor - symmetrical, limited to upper limbs, nonprogressive
nausea
diarhooea
polydipsia/polyuria
lithium induced toxic impairment
Pregnancy risk with lithium
congenital cardiac malformations
Moderate lithium toxicity
GIT upset
CNS - coarse/worsening tremor, ataxia
Severe lithium toxicity
disorientation
seizures
coma
death
Lithium contraindications
renal impairment
diuretics
sodium depletion
dehydration
CVS disease
psoriasis
What does valproate do to pregnancy
neural tube defects
neurodevelopmental issues
Valproate side effects
V - vomiting
A - Alopecia
L - Liver toxicity
P - Pancreatitis/Pancytopenia
R - Retention of fat (weight gain)
O - Oedema
A - Appetite increase
T - tremor
E - Enzyme inducer (liver)
Carbamazepine major drug interaction
COCP
What birth control should you use with Valproate
IUD/Implanon
Most common complication of Lithium
AKI
Carbamazepine SE
sedative
dizziness
ataxia
Carbamazepine severe SE
TEN
SJS
Aplastic anaemia
Agranulocytosis
How to prevent complications of Lamotrigine
“no rush no rash”
(slow titrating to prevent SJS/TEN)
Lithium tremor
symmetrical
upper limbs
nonprogressive (unless toxic)
