Antipsychotics Flashcards
Serotonin SE
EPS
Sexual dysfunction
Weight gain
Dopamine SE
Neurological
Hyperprolactinemia
QTc prolongation
Histamine SE
sedation
cholesterol/weight gain
Anticholinergic (NA) SE
constipation
blurred vision
dry mouth
Alpha 2 SE
postural HTN
Rare antipsychotic side effects
agranulocytosis
neuromalignant syndrome
cholestasis
ocular pathology
First generation/typical antipsychotics
Chlorpromazine
Haloperidol
Pericyazine
Zuclopenthixol
Atypical antipsychotics
Clozapine
Risperidone
Paliperidone
quetiapine
amisulpride
3rd Generation antipsychotics
aripiprazole
Signs of EPS
Acute dystonic reactions
Parkinsonism
Akathisia
Tardive dyskinesia
Signs of Neuroleptic Malignant Syndrome
fever
gross CK elevation
muscle rigidity
mental status change
autonomic instability
rhabdomyolysis
Risperidone/paliperidone SE
high prolactin
Haloperidol indication
amphetamine-induced psychosis
Why should you not change smoking habits on clozapine
smoking lowers blood concentration of clozapine - suddenly stopping will increase levels –> respiratory arrest (aka if you stop smoking randomly you will die)
clozapine rebound psychosis
Why is clozapine last-line
cholinergic side effects
weight gain
hypotension if fast titration
severe constipation
Clozapine SE
agranulocytosis
neutropenia
myocarditis
nocturnal hypersalivation
hypotension (sedation, dizziness)
What receptor do antipsychotics mainly work on
D2
