Mood stabilisers Flashcards
Examples of mood stabilisers
Sodium valproate
Lithium
Lamotrigine
Carbamazepine
What can be used as mood stabilisers that are used in another area of psychiatry?
Antipsychoitcs eg olanzapine, risperidone, quetiapine, asenapine
What to consider when precribing psychotropic medication for patient?
Comorbidities
Renal impairment
Hepatic impairment
Concordance
Age
Other medication
Past experience/treatments
Advanced directive
Whatto ask about mood stabiliser hisotry?
Brand if lithium
Clozapine - SCR/MIG/HIE if on
Depot meds
OTC/herbal meds
Illicit drugs/novel psychoactive substances
SMoking status
What happens to clozapine levels when someone stops smoking?
Increases
What indisc CYPA12 activity in smoking? How many cigs a day is sufficient for maximum induction of this enzyme?
Polycyclic aromatic hydrocarbons
7-12 cigarettes/day
What happens to clozapine metabolism when a patient is smoking
Metabolism of clozapine INCREASED -> reduced clozapine plasma levels
Why do smokers require higher doses of clozapine?
To achieve same plasma level as non smoker due to increased CYPA12 metabolism
