Antipsychotics Flashcards
What do antipsyhcoitcs do?
Antagonise dopamine receptors to varying extents with other receptors
What positive symptoms do antipsychotics diminish?
Hallucinations
Delusions
Thought disorder
What engative symptoms can antipsychotics sometimes improve?
Lack of motivation
Blunted affect
Cognitive impairment
Why are antipsychotics important in relaspe prevention?
Long term use
What side effect are first generation antipsychotics known for?
Extrapyramidal side effects
What main side effect do second generation antipsychotics cause?
Cardiometabolic risks
How to choose an antipscyhotics?
NICE guidance
Patient choice, empowerment, shared decision making
Side effect profile
Comorbidities eg diabetic, renal impairment
Prev treatment
CATIE/CUTLASS
FGA vs SGA
Patient concordance - depot or oral prep
Patient choice formulation
What are FGAs ass with?
EPSE
Hyperprolactinaemia
TD
What drug use if treatment resistant psychosis?
Clozapine
Are SGAs better tolerated than FGAs?
No – no more effective or better tolerated than FGAs for patients with chronic schizophrenia
What is the worst and best antipsychotic for withdrawal?
-Amisulrpide is best
-Haloperidol is worst
What antipsychotic is most likely to cause weight gain? And least?
Worst – olanzapine
Best – haloperidol
What antipsychotics are best and worst for hyperprolactinaemia?
Aripiprazole
Paliperidone
What antipsychotics are best and worst for hyperprolactinaemia?
Aripiprazole
Paliperidone
Main EPSE symtpoms
Pseurdo-parkinsonism, dystonia, tardice dyskinesia, akathisia
