Mood Disorders Flashcards
How do mood disorders differ from mood?
Disorders involve disabling mood disturbance. Differs from sadness/happiness in intensity, duration, impairment and associated symptoms.
What qualifies as a major depressive episode?
≥ 5 symptoms, nearly daily, for ≥ 2 weeks
Defining characters of major depressive episode
Sad/depressed OR loss of interest in usual activities (anhedonia)
Symptoms of major depressive episode
- Significant change in weight or appetite
- Difficulties in sleeping
- Psychomotor retardation/agitation (slow down/can’t sit still)
- Loss of energy or fatigue
- Worthlessness or guilt
- Difficulty concentrating or making decisions
- Recurrent thoughts of suicide or death
Major depressive disorder (MDD)
≥ 1 episode of depression
Lifetime prevalence of MDD
16% (most common in 18-29 year olds)
Average age of onset of MDD
25 years
Sex/cultural differences in MDD
- Affects rates and presentation of symptoms
- Greater in women, Latinx/Hispanic
- Less in African Americans
Persistent depressive disorder
Milder depressed mood for most of the day more days than not for ≥ 2 years
Premenstrual dysphoric disorder
Severe, disabling form of PMS
Biological factors for MDD
35% heritability. Involves genetic, neuroendocrine and neurotransmitter related factors.
Genetic factors for MDD
- Multiple genes
- Interact with environmental stress
Neuroendocrine factors for MDD
- Chronically elevated cortisol
- HPA hyperactivity
- Related to early stress (childhood stress)
- Reduces neurogenesis (generation of neurons)
Neurotransmitters involved in MDD
- Low serotonin = poor regulation of sleep, emotion, appetite
- Permissive hypothesis = serotonin -> dysregulation of norepinephrine and dopamine
- Balance of NTs important
Beck’s negative cognitive triad
Negative views of self, world, future
Cognitive distortions
- All or nothing: it’s all bad
- Catastrophizing: thinking the worst will happen
- Mental filter: dwelling on negative details
- Overgeneralization: a negative event is likely to happen again and again
- Personalization: self-blame
Learned helplessness theory
Serves as a behavioral explanation. People may become depressed because they learn to view
themselves as helpless to control their environment.
Cognitive vulnerabilities
- Negative cognitive triad
- Internal, stable and global attributions
- Rumination
Internal attribution
Blaming oneself for a situation
Stable attribution
Event was due to unchanging, permanent factors and will happen again
Anxious features subtype of depression
Prominent anxiety symptoms as well as depressive symptoms
Mixed features subtype of depression
Meet the criteria for a major depressive disorder and have at least 3 symptoms of mania, but they do not meet the full criteria for a manic episode.
Melancholic features subtype of depression
Physiological symptoms of depression are particularly prominent (e.g. weight loss, psychomotor retardation); anhedonia
Psychotic features subtype of depression
Experience delusions and hallucinations; can be mood-congruent (related to typical themes of depression such as worthlessness) or mood-incongruent
Catatonic features subtype of depression
Catatonic behaviors: not actively relating to environment, mutism, posturing, agitation, mimicking another’s speech or movements
Atypical features subtype of depression
Odd assortment of symptoms (e.g. positive mood reactions to some events, significant weight gain or increase in appetite, hypersomnia, sensitivity to interpersonal rejection)