MOOD 6

Question 1

What do PET studies show in depressed patients?

Answer 1

PET = decreased perfusion and metabolism in the pre-frontal region (L>R)

(of note: MRI shows decreased volume of hippocampus and caudate nucleus)

Question 2

What is the age cutoff for “late onset” depression?

What is an important etiological feature of late onset depression?

Answer 2

65 years old.

Less associated with life event and more commonly due to secondary causes (major NCD, structural CNS disease)

Question 3

MDD is MOST comorbid with what other disorder?

Answer 3

Anxiety disorders (59%)

Question 4

What is the average age of onset for MDD?

Answer 4

29

Question 5

What is the lifetime prevalence for MDD?

What is the 12 month prevalence for MDD?

Answer 5

Lifetime = 17%

12 month prevalence = 6%

Question 6

What percentage of individuals who initially present with a depressive episode go onto BPAD?

Answer 6

5-10%

Question 7

What percentage of individuals with MDD commit suicide?

Answer 7

15%

Question 8

What is the F:M lifetime prevalence of MDD?

Answer 8

F>M

lifetime prevalence is 1.7:1 F:M

Question 9

MDD is highly comorbid with anxiety disorders, impulse control disorders and substance use disorders….what is the % comorbid with each of these?

Answer 9

Anxiety (59%)
Substance abuse (25%)
Impulse control disorder (30%)

Question 10

What is the average length of a MDD episode?

What % are in full remission after 6 months?

2 years?

Answer 10

3 months

6 months = 63% remission

2 years = 80 % remission (this means 20% meet criteria for Persistent Depressive Disorder)