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Immunology Week 1 Cards > Mononuclear Phagocytes > Flashcards

Mononuclear Phagocytes Flashcards

1
Q

MP development into a resident monocyte by stage

A

Hemopoietic Stem Cell –> Granulocyte/Monocyte-colony forming unit (GM-CFU)—> M-CFU influenced —> monoblast –> pro-monocyte —> inflammatory monocyte —> resident monocyte

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2
Q

Inflammatory monocyte is represented as

Resident monocyte is represented as

A

GR1(+)

GR1(-)

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3
Q

Monocyte/Macrophages by tissue:

Lung
Liver
Connective tissue 
Spleen
Bone 
CNS
A

lung = alveolar macrophage
liver = kupffer cell
connective tissue = histiocyte
spleen = white pulp macro, marginal zone macro, metallophilic macro

CNS = microglial cell
Bone = osteoclast
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4
Q

Functions of Monocyte/Macrophages (1-6)

A
  1. Activation
  2. Chemotaxis, tissue inflammation
  3. Phagocytosis, scavenger
  4. Effector function
  5. Antigen presentation
  6. immunomodulation
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Immunology Week 1 Cards (7 decks)

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