Dendritic Cells

Question 1

Location of Dendritic Cells

Answer 1

epithelia and connective tissues

Question 2

Function of dendritic cells

Answer 2

capture microbes, digest their proteins
into fragments, express on their surface microbial peptides

also carry antigenic cargo to draining lymph nodes through which naive T lymphocytes are continuously recruited

Question 3

Maturation of a Dendritic Cell

Answer 3

Arise from a common precursor cell of the myeloid lineage in the bone marrow

Question 4

Differentiation of Dendritic Cells

Answer 4

They mature from myeloid lineage in the bone marrow, after which they differentiate into subsets

Classical DCs (the major one)
plasmacytoid DCs (pDCs) 

Inflammatory DCs may mature from monocytes in inflamed tissues

Question 5

a special tissue-resident dendritic cell called ______ come from where?

Answer 5

Langerhan cells in the skin

appears early life, may develop from embryonic precursors

Question 6

DCs: precursors — > final form

Answer 6

BONE MARROW

Hematopoietic stem cell —> monocyte/dendritic cell precursor —? common dendritic cell precursor —>

a ) Pre-classical DC—> classical DC

b) Plasmacytoid DC —> Plasmacytoid DC
- —————-

monocyte —> inflammatory DC

                   ------------------

                       FETUS 

Fetal hemapoietic organs –> Hematopoietic stem cells —->
Embryonic tissue precursor —-> Langerhan Cell