Monogenic diabetes

Question 1

Definition

Answer 1

Not type 1 or type 2 diabetes

Single gene abnormality causes the disease

Question 2

Which 2 types of diabetes does it comprise of?

Answer 2

MODY

Neonatal diabetes

Question 3

MODY - who gets it

Answer 3

Onset usually below the age of 30

Question 4

MODY - genetics

Answer 4

Autosomal dominant inheritance

Question 5

MODY - types

Answer 5

Glucokinase

Transcription factor

Question 6

MODY - glucokinase patients - definition

Answer 6

MODY caused by glucokinase mutation which alters the function of GLUT2 by making it less responsive to glucose.
Blood glucose levels get much higher before insulin is secreted

Question 7

MODY - glucokinase patients - onset

Answer 7

Birth

Question 8

MODY - glucokinase patients - management

Answer 8

Stable diet control

Question 9

MODY - transcription factor patients - definition

Answer 9

MODY caused by transcription factor mutation

Question 10

MODY - transcription factor patients - onset

Answer 10

Adolescence

Question 11

MODY - transcription factor patients - management

Answer 11

Start with diet control

May need medication

Question 12

Neonatal diabetes - management

Answer 12

Insulin for the first 3 months of life
Check blood glucose levels
Child shouldn’t need life long insulin therapy