Miscellaneous Reproductive Endocrinology Flashcards
Idiopathic hypogonadotrophic hypogonadism - definition
Absent / delayed sexual development in the absence of any anatomical or functional defects of the hypothalamic-pituitary-gonadal axis
Idiopathic hypogonadotrophic hypogonadism -endocrine function
Decreased GnRh
Decreased levels of LH and FSH
Idiopathic hypogonadotrophic hypogonadism - which mutation causes this
Mutation of kisspeptin
Idiopathic hypogonadotrophic hypogonadism - clinical features
Absent or incomplete puberty
Idiopathic hypogonadotrophic hypogonadism - investigations
MRI (normal pituitary function)
Kallman’s syndrome - definition
Loss of GnRh secretion but the remainder of pituitary function is normal
Kallman’s syndrome - clinical features
Asomnia (loss of smell)
Primary male hypogonadism - endocrine function
Problem is at the testes
Decreased testosterone
Increased LH, FSH
Primary male hypogonadism - cause
Congenital (kilnefelters)
Secondary male hypogonadism - endocrine function
Problem is at the brain
Decreased testosterone
Inappropriately low LH, FSH
Secondary male hypogonadism - cause
Pituitary / hypothalamic disease
Male hypogonadism - clinical features
Delayed puberty
Lack of sexual interest
Male hypogonadism - investigations
Measure testosterone, LH, FSH
Male hypogonadism - management
Testosterone replacement
Testosterone improves spine and hip bone mass density - true or false?
True
