Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Endocrine SOH > Hypothyroidism > Flashcards

Hypothyroidism Flashcards

1
Q

Definition

A

Arises due to any disorder that results in insufficient secretion of thyroid hormones from the thyroid gland
Underachieve thyroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Clinical features - general

A 
Weight gain 
Decreased appetite 
Pale 
Cool skin that feels doughy 
Expressionless face 
Orange tinge to skin 
Dry skin
Vitiligo
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Clinical features - pulse

A

Bradycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Clinical features - eyes

A

Periorbital puffiness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Clinical features - hair

A

Course

Sparse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Clinical features - CNS

A

Cold intolerance
Depression
Obstructive sleep apnoea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Clinical features - throat

A

Atrophy of the thyroid gland

Hoarse voice

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Clinical features - CVS

A

Worsening of heart failure
Cardiac dilation
Pitting oedema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Clinical features - GI

A

Constipation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Clinical features - gynae

A

Heavy periods

oligomenorrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Management

A

Tevothyroxine (T4)

- may also be prescribed T3 but this isn’t routinely

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Thyroxine - dosage (young pt, old pt)

A

Young: 50-100mcg daily
Old: 25-50mcg daily

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Thyroxine - pregnancy

A

Increase thyroxine dosage to 25mcg during pregnancy

- there is increased levels of thyroid binding protein during pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Thyroxine - compliance

A

Check compliance in patients by looking at the thyroid function
If T3/T4 levels are normal but TSH levels remain raised, then the patient is not compliant with medication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Primary hypothyroidism - definition

A

Disease affecting the thyroid gland itself

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Primary hypothyroidism - thyroid function

A

Decreased T3/T4 levels

Increased TSH

17
Q

Primary hypothyroidism - autoimmune cause

A

Hashimotos thyroiditis

18
Q

Primary hypothyroidism - goitrous causes

A 
Autoimmune - hashimotos thyroiditis 
Iodine deficiency 
Drug induced (lithium, amiodarone)
19
Q

Primary hypothyroidism - non goitrous causes

A 
Atrophic thyroiditis (same as hashimotos but no goitre)
Iatrogenic (radiotherapy, chemotherapy)
Congenital developmental delay
20
Q

Primary hypothyroidism - investigations

A

Increased CK enzyme
Increased LDL cholesterol
Biochemical testing
Imaging

21
Q

Primary hypothyroidism - management

A

Thyroxine replacement

22
Q

Hashimotos thyroiditis - definition

A

Autoimmune destruction of the thyroid gland causing hypothyroidism

23
Q

Hashimotos thyroiditis - who gets it

A

Middle aged females (age 40-60)

24
Q

Hashimotos thyroiditis - Pathogenesis

A

Destruction of follicular epithelial cells by CD8+ T cells

25
Q

Hashimotos thyroiditis - auto-antibodies

A

Anti-TPO +ve in most patients
Anti-thyroglobulin
TRAb +ve in a few patients

26
Q

Hashimotos thyroiditis - management

A

Thyroxine

27
Q

Hashimotos thyroiditis - associated conditions

A 
Risk of developing B cell non Hodgkins lymphoma 
Coeliac disease (anti TTG +ve)
28
Q

Secondary hypothyroidism - definition

A

Hypothalamic or pituitary disease with no thyroid gland pathology

29
Q

Secondary hypothyroidism - thyroid function

A

Decreased level of T3, T4

Normal / decreased TSH level

30
Q

Secondary hypothyroidism - management

A

Thyroxine

31
Q

Subclinical hypothyroidism - thyroid function

A

Normal levels of T3, T4

Increased TSH level

32
Q

Subclinical hypothyroidism - management

A

Treat if TSH level is > 10

Always treat in pregnancy

33
Q

Cretinism - definition

A

Deficiency of thyroid hormones present at birth

34
Q

Cretinism - clinical features

A

Dwarfism

Limited mental functioning

35
Q

Severe hypothyroidism - myxoedema coma definition

A

Affects people with long standing but frequently unrecognised hypothyroidism

Endocrine SOH (25 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions