Monoclonal Antibodies

Question 1

What are monoclonal antibodies?

Answer 1

Monoclonal antibodies are identical antibodies produced from a single clone of B cells, designed to target a specific antigen.

Question 2

True or False: Monoclonal antibodies can be used in diagnostic tests.

Answer 2

True

Question 3

Fill in the blank: Monoclonal antibodies are produced by __________.

Answer 3

hybridomas

Question 4

What is the main use of monoclonal antibodies in medicine?

Answer 4

They are used for targeted therapy in diseases such as cancer and autoimmune disorders.

Question 5

Which cell type is fused with an immortal myeloma cell to produce monoclonal antibodies?

Answer 5

B lymphocytes

Question 6

Multiple Choice: Which of the following is NOT a use of monoclonal antibodies? A) Cancer treatment B) Blood transfusions C) Pregnancy tests D) Targeted drug delivery

Answer 6

B) Blood transfusions

Question 7

What is the process of creating monoclonal antibodies called?

Answer 7

Hybridoma technology

Question 8

True or False: Monoclonal antibodies are specific to a single epitope on an antigen.

Answer 8

True

Question 9

What type of immune response do monoclonal antibodies mimic?

Answer 9

The humoral immune response

Question 10

Fill in the blank: Monoclonal antibodies can be labeled with __________ for imaging purposes.

Answer 10

radioisotopes

Question 11

Short answer: Name one advantage of using monoclonal antibodies over polyclonal antibodies.

Answer 11

Monoclonal antibodies provide consistent and specific targeting of antigens.

Question 12

What is the role of the myeloma cell in monoclonal antibody production?

Answer 12

It provides a continuous supply of antibodies by being immortal.

Question 13

Multiple Choice: Which of the following diseases can be treated with monoclonal antibodies? A) HIV B) Influenza C) Cancer D) All of the above

Answer 13

C) Cancer

Question 14

True or False: Monoclonal antibodies can only be produced in laboratories.

Answer 14

False

Question 15

What is the significance of the ‘clonal’ aspect of monoclonal antibodies?

Answer 15

It indicates that all antibodies are derived from a single B cell clone, ensuring uniformity.

Question 16

Fill in the blank: Monoclonal antibodies can be used in __________ therapy to treat autoimmune diseases.

Answer 16

immunosuppressive

Question 17

Short answer: How do monoclonal antibodies assist in cancer treatment?

Answer 17

They can target and bind to specific cancer cells, marking them for destruction by the immune system.

Question 18

What is one way that monoclonal antibodies can be used in research?

Answer 18

To detect specific proteins or antigens in laboratory assays.

Question 19

True or False: Monoclonal antibodies can be engineered to deliver drugs directly to target cells.

Answer 19

True

Question 20

Fill in the blank: The first monoclonal antibody was produced in the year __________.

Answer 20

1975

Question 21

Multiple Choice: Which of the following is a common method for producing monoclonal antibodies? A) PCR B) Cell culture C) Gene editing D) Electrophoresis

Answer 21

B) Cell culture

Question 22

What are the ethical considerations in the use of monoclonal antibodies?

Answer 22

Concerns include animal welfare in the production process and potential side effects in human treatments.

Question 23

Fill in the blank: Monoclonal antibodies can be used in __________ tests to confirm pregnancy.

Answer 23

immunoassay

Question 24

Short answer: Describe one limitation of monoclonal antibodies.

Answer 24

They can be expensive to produce and may have limited effectiveness against certain targets.

Question 25

True or False: Monoclonal antibodies can be used for both therapeutic and diagnostic purposes.

Answer 25

True

Question 26

What is an example of a monoclonal antibody used in cancer treatment?

Answer 26

Rituximab

Question 27

Fill in the blank: The __________ is the part of the antibody that binds to the antigen.

Answer 27

variable region

Question 28

Multiple Choice: What does the term 'monoclonal' refer to? A) Many clones B) A single clone C) No clones D) Clones of different types

Answer 28

B) A single clone

Question 29

Short answer: What is the difference between monoclonal and polyclonal antibodies?

Answer 29

Monoclonal antibodies are identical and derived from one clone, while polyclonal antibodies are a mixture from different B cell clones.