Monoclonal Antibodies Flashcards
What are monoclonal antibodies?
Monoclonal antibodies are identical antibodies produced from a single clone of B cells, designed to target a specific antigen.
True or False: Monoclonal antibodies can be used in diagnostic tests.
True
Fill in the blank: Monoclonal antibodies are produced by __________.
hybridomas
What is the main use of monoclonal antibodies in medicine?
They are used for targeted therapy in diseases such as cancer and autoimmune disorders.
Which cell type is fused with an immortal myeloma cell to produce monoclonal antibodies?
B lymphocytes
Multiple Choice: Which of the following is NOT a use of monoclonal antibodies? A) Cancer treatment B) Blood transfusions C) Pregnancy tests D) Targeted drug delivery
B) Blood transfusions
What is the process of creating monoclonal antibodies called?
Hybridoma technology
True or False: Monoclonal antibodies are specific to a single epitope on an antigen.
True
What type of immune response do monoclonal antibodies mimic?
The humoral immune response
Fill in the blank: Monoclonal antibodies can be labeled with __________ for imaging purposes.
radioisotopes
Short answer: Name one advantage of using monoclonal antibodies over polyclonal antibodies.
Monoclonal antibodies provide consistent and specific targeting of antigens.
What is the role of the myeloma cell in monoclonal antibody production?
It provides a continuous supply of antibodies by being immortal.
Multiple Choice: Which of the following diseases can be treated with monoclonal antibodies? A) HIV B) Influenza C) Cancer D) All of the above
C) Cancer
True or False: Monoclonal antibodies can only be produced in laboratories.
False
What is the significance of the ‘clonal’ aspect of monoclonal antibodies?
It indicates that all antibodies are derived from a single B cell clone, ensuring uniformity.
Fill in the blank: Monoclonal antibodies can be used in __________ therapy to treat autoimmune diseases.
immunosuppressive
Short answer: How do monoclonal antibodies assist in cancer treatment?
They can target and bind to specific cancer cells, marking them for destruction by the immune system.
What is one way that monoclonal antibodies can be used in research?
To detect specific proteins or antigens in laboratory assays.
True or False: Monoclonal antibodies can be engineered to deliver drugs directly to target cells.
True
Fill in the blank: The first monoclonal antibody was produced in the year __________.
1975
Multiple Choice: Which of the following is a common method for producing monoclonal antibodies? A) PCR B) Cell culture C) Gene editing D) Electrophoresis
B) Cell culture
What are the ethical considerations in the use of monoclonal antibodies?
Concerns include animal welfare in the production process and potential side effects in human treatments.
Fill in the blank: Monoclonal antibodies can be used in __________ tests to confirm pregnancy.
immunoassay
Short answer: Describe one limitation of monoclonal antibodies.
They can be expensive to produce and may have limited effectiveness against certain targets.