Monoclonal Antibodies Flashcards
Monoclonal Antibodies Drug Names
Adalimumab
certolizumab
golimumab
infliximab
“-mab”
Monoclonal Antibodies Therapeutic Actions
• It reacts as an antibody to human T cells, disabling the T cells and acting as an immune suppressor
Monoclonal Antibodies Indications
- Antibodies that attach to specific receptors
Monoclonal Antibodies Contraindication and Cautions
Contraindications: • Known allergy • Fluid overload • Fever • Pregnancy and lactation
Monoclonal Antibodies DDI
DDI:
• Severe immune suppression can occur with the use of other suppressants
Monoclonal Antibodies Adverse Effect
- Pulmonary edema
- Fluid retention,
- Flu-like symptoms
Monoclonal Antibodies:
Assessment
Assess:
Hx: Contraindications and cautions
Physical: vital signs, weight, temp, orientation and reflexes (baseline)
Labs: baseline ECG
Monoclonal Antibodies:
Diagnosis
Dx:
- Acute pain: to CNS, GI and flu-like effects
- Risk for infection related to immune suppression
- Imbalanced nutrition: less than body requirements, related to nausea and vomiting
- Deficient knowledge: drug therapy
Monoclonal Antibodies:
Implementation
Implementation:
• Arrange for laboratory tests before and periodically during therapy
• Administer the drug as indicated; instruct the patient and a significant other if injections are required
• Protect the patient from exposure to infections and maintain a strict aseptic technique for any invasive procedures
• Monitor nutritional status during therapy; provide small, frequent meals, mouth care, and nutritional consultation
• Instruct females in use of barrier contraceptives
• Suggest another method of feeding the baby
• Provide thorough patient teaching
Monoclonal Antibodies: Evaluation
Eval: Response to the drug Adverse effects Effectiveness of comfort measures Compliance with the regimen Effectiveness of the teaching plan
