Interleukins ^

Question 1

Interleukins Drug Names

Answer 1

Aldesleukin
- Human interleukin produced by recombinant DNA technology using Escherichia coli bacteria

Oprelvekin
- A newer agent produced by DNA technology

Question 2

Interleukins Therapeutic Actions

Answer 2

• Increase the number of natural killer cells and lymphocytes
• Activates cellular immunity and inhibits tumor growth
• Communicate between lymphocytes, stimulate cellular immunity and inhibit tumor growth

Question 3

Interleukins Indication

Answer 3

• Aldesleukin: Specific renal carcinomas; possible treatment of AIDS and AIDS-related disorders
• Oprelvekin: Prevention of severe thrombocytopenia after myelosuppressive chemotherapy

Question 4

Interleukins Contraindications and Cautions

Answer 4

Contraindications:
Known allergy, pregnancy, and lactation

Cautions:
Renal, liver, or cardiovascular impairment

Question 5

Interleukins Adverse Effects

Answer 5

Lethargy, myalgia, arthralgia, fatigue, fever, respiratory difficulties, depression with suicidal ideation

Question 6

Interleukins:

Assessment

Answer 6

Assessment
History and physical exam
Assess for contraindications and cautions: Known allergies, pregnancy or lactation, history of hepatic, renal, or cardiac disease; bone marrow depression; leukemic states; and CNS disorders
Skin lesions, weight, monitor temperature, check heart rate and rhythm and blood pressure, orientation and reflexes
Obtain a baseline ECG
Monitor the results of laboratory tests

Question 7

Interleukins:

Diagnosis

Answer 7

Diagnoses
Acute pain related to CNS, GI, and flu-like effects
Imbalanced nutrition: Less than body requirements related to flu-like effects
Anxiety related to diagnosis and drug therapy
Deficient knowledge regarding drug therapy

Question 8

Interleukins Implementation

Answer 8

Implementation
Arrange for laboratory tests before and periodically during therapy
Administer drug as indicated; instruct the patient and a significant other if injections are required
Monitor for severe reactions
Instruct female patients in the use of barrier contraceptives to avoid pregnancy
Provide patient teaching

Question 9

Interleukins:

Evaluation

Answer 9

Evaluation
Monitor patient response to the drug (improvement in condition being treated)
Monitor for adverse effects (flu-like symptoms, GI upset, CNS changes, bone marrow depression)
Evaluate the effectiveness of the teaching plan
Monitor the compliance with the regimen