Colony-Stimulating Factors ^

Question 1

Colony-Stimulating Factors Drug Name

Answer 1

Filgrasium

Question 2

Colony-Stimulating Factors Therapeutic Actions

Answer 2

• Increase the production of neutrophils in the bone marrow with little effect on other hematopoietic cells
• Can be used to reduce the incidence of infection in patients with bone marrow suppression, to decrease the neutropenia associated with bone marrow transplants and chemotherapy, and to help in the treatment of various blood-related cancers.

Question 3

Colony-Stimulating Factors Indications

Answer 3

• Reduction of the incidence of infection
• reduction in time to neutrophil recovery time to neutrophil recovery with myelosupressive chemotherapy, leukemia, bone marrow transplant
• increase the production of white blood cells by working in the bone marrow

Question 4

Colony-Stimulating Factors Contraindications and Cautions

Answer 4

Contraindications:

Allergy to any component of the drug, pregnancy, lactation, renal or hepatic disease, radiation and chemotherapy

Question 5

Colony-Stimulating Factors DDI

Answer 5

DDI

increase in the myeloproliferative effects of sargramostim when combined with lithium or corticosteroids

Question 6

Colony-Stimulating Factors Adverse Effects

Answer 6

GI related, headache, fatigue, generalized weakness, alopecia and dermatitis, and generalized pain and bone pain

Question 7

Colony-Stimulating Factors:

Assessment

Answer 7

Assessment
History and physical exam
Assess for contraindications and cautions: Known allergies, pregnancy or lactation, history of hepatic, renal, or cardiac disease; bone marrow depression; leukemic states; and CNS disorders
Skin lesions, weight, monitor temperature, check heart rate and rhythm and blood pressure, orientation and reflexes
Obtain a baseline ECG
Monitor the results of laboratory tests

Question 8

Colony-Stimulating Factors:

Diagnosis

Answer 8

Diagnoses
Acute pain related to CNS, GI, and flu-like effects
Imbalanced nutrition: Less than body requirements related to flu-like effects
Anxiety related to diagnosis and drug therapy
Deficient knowledge regarding drug therapy

Question 9

Colony-Stimulating Factors:

Implmentation

Answer 9

Implementation
Arrange for laboratory tests before and periodically during therapy
Administer drug as indicated; instruct the patient and a significant other if injections are required
Monitor for severe reactions
Instruct female patients in the use of barrier contraceptives to avoid pregnancy
Provide patient teaching

Question 10

Colony-Stimulating Factors:

Evaluation

Answer 10

Evaluation
Monitor patient response to the drug (improvement in condition being treated)
Monitor for adverse effects (flu-like symptoms, GI upset, CNS changes, bone marrow depression)
Evaluate the effectiveness of the teaching plan
Monitor the compliance with the regimen