Molecular Medicines Flashcards
What is Factor VIII? Name its drug class, indication, and mechanism of action.
Factor VIII is a coagulation factor used for haemophilia A. Its mechanism of action is replaces deficient FVIII restoring clotting cascade.
What is Human chorionic gonadotrophin (HCG)? Name its drug class, indication, and mechanism of action.
Human chorionic gonadotrophin (HCG) is a hormone used for infertility. Its mechanism of action is stimulates ovarian rupture
What is Erythropoeitin (EPO)? Name its drug class, indication, and mechanism of action.
Erythropoeitin (EPO) is a hormone used for anaemia. Its mechanism of action is stimulates erythropoeisis.
What is Tenecteplase? Name its drug class, indication, and mechanism of action.
Tenecteplase is a tissue plasminogen activator (TPA) used for acute myocardial infarction. Its mechanism of action is dissolution of thrombus.
What is Infliximab? Name its drug class, indication, and mechanism of action.
Infliximab is a naked MAB used for Crohn’s and rheumatoid arthritis. Its mechanism of action is binds to TNFa and neutralises its inflammatory actions.
What is Alemtuzumab? Name its drug class, indication, and mechanism of action.
Alemtuzumab is a naked MAB used for B-cell chronic lymphocytic leukaemia. Its mechanism of action is binds to CD52 antigen on B and T cells causing their lysis.
What is Abciximab? Name its drug class, indication, and mechanism of action.
Abciximab is a naked MAB used for cardiac ischaemia. Its mechanism of action is binds to GPIIb/IIIa receptor on platelet preventing aggregation.
What is Trastuzumab? Name its drug class, indication, and mechanism of action.
Trastuzumab is a naked MAB used for breast cancer. Its mechanism of action is binds to overexpressed HER2 protein in breast tissue preventing EGF action.
What is Ibrutumomab tiuexetan? Name its drug class, indication, and mechanism of action.
Ibrutumomab tiuexetan is a conjugated MAB used for B-cell non-Hodgkin lymphoma. Its mechanism of action is directed against CD20 antigen conjugated with Y-90 radionucleotide.
What is Gemtuzumab ozogamicin? Name its drug class, indication, and mechanism of action.
Gemtuzumab ozogamicin is a conjugated MAB used for relapsed acute myelogenous leukaemia. Its mechanism of action is directed against CD233 antigen conjugated with calicheamicin (a chemotherapeutic agent).
What is OspA? Name its drug class, indication, and mechanism of action.
OspA is a vaccine used for Lyme disease. Its mechanism of action is vaccine raised against OspA protein of spirochaete Borrelia burgdorferi.
What is Gardasil? Name its drug class, indication, and mechanism of action.
Gardasil is a vaccine used for cervical cancer and genital warts. Its mechanism of action is vaccine raised against various coat proteins of HPV.
