Molecular Bioogy of Receptors Flashcards

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0
Q

Describe the structure of a metabotropic receptor?

A

Monomeric, 7-TM domains, extra cellular for NT binding and intracellular for G-proteins

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1
Q

What are three tetrameric ionotropic receptors for glutamate?

A

AMPA, NMDA and kainate

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2
Q

What inhibits GABAa receptors?

A

Picrotoxin inhibits by blocking chloride ions and changing the membrane potential to be further from threshold.

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3
Q

How many subunits can ionotropic receptors have?

A

3,4 or 5

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4
Q

How many helices do the ionotropic receptors have?

A

4 or 3 with a pore loop

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5
Q

What lines the channel of an ionotropic receptor?

A

Either the second helice or the pore loop. They control the flow

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6
Q

What the ways can ion channels be opened by?

A

Chemicals (ligand-gated), voltage, and mechanosensory

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7
Q

Describe the structure of a nicotinic acetylcholine receptor and what is it permeable to?

A

5 subunits, 4 helices in each. Acetylcholine binds to the alpha subunits. Permeable to sodium and potassium and sometimes calcium

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8
Q

What are the two types of receptors?.

A
  1. Ligand-gated ion channels or ionotropic

2. G-protein coupled receptors or metabotropic.

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9
Q

How do ionotropic receptors work?

A

Several proteins form a channel when NT binds the channel opens, either cationic or anionic, rapid.

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10
Q

Explain how NMDA receptors work?

A

At resting potential the channel is blocked by magnesium, it’s only active drying high frequency stimulation. Magnesium is exposed post-depolarisation as driving force is removed, glycine is a co-agonists and D-Serine.

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11
Q

How many classes of different G-protein coupled receptors are there?

A

8- glutamate, GABAb, dopamine, noradrenaline, adrenaline, histamine, serotonin, purines and muscarinic.

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