Molecular Biology of Cancer Flashcards
1
Q
what is Peto’s paradox?
A
lack of correlation between body size and cancer risk
2
Q
what do whales and dolphins have to prevent cancer?
A
over-represented (amplified) genes involved in tumour suppression and regulation of immune defence
3
Q
what do elephants have to prevent cancer?
A
extra copies of p53 and LIF, incompletely duplicated LIF which can activate apoptosis
4
Q
what is the function of Everolimus?
A
binds to mTORC1 and inhibits mTOR kinase activity
5
Q
what is ecDNA?
A
extrachromosomal DNA
6
Q
what is mtDNA?
A
mitochondrial DNA
