MODY and Neonatal Diabetes

Question 1

MODY stands for what?

Answer 1

Maturity Onset diabetes of the young

Question 2

MODY subtype of what condition?

Answer 2

T2DM

Question 3

surgical sieve MODY?

Answer 3

genetic

Question 4

MODY:

is there obesity?

Answer 4

no

Question 5

MODY:

is there ketosis?

Answer 5

no

Question 6

what inheritance pattern is MODY?

Answer 6

autosomal dominant

Question 7

is MODY rare or common?

Answer 7

rare

Question 8

MODY mild or severe disease?

Answer 8

mild

Question 9

usual Mx?

Answer 9

no medication needed, just control diet better.

Question 10

what gene commonly mutated in MODY 3?

Answer 10

HNF1A

Question 11

Neonatal Diabetes is a subtype of what condition?

Answer 11

T2DM

Question 12

how man types of neonatal diabetes are there?

Answer 12

2

Question 13

which type of neonatal diabetes is milder?

Answer 13

type 2

Question 14

which type of neonatal diabetes is permanent?

Answer 14

type 1

Question 15

treatment for type 1 neonatal diabetes?

how long will they be on this treatment?

Answer 15

insulin

rest of their life

Question 16

which type of neonatal diabetes is transient?

Answer 16

type 2

Question 17

outline pathophys of type 1 neonatal diabetes?

- step by step

Answer 17

IUGR > pancreas underdeveloped > Beta cells not making insulin > symptomatic hyperglycaemia > ketoacidosis

Question 18

outline pathophys of type 2 neonatal diabetes?
- step by step

type 2 neonatal diabetes usually resolves by when?

Answer 18

severe IUGR > pancreas underdeveloped > Beta cells make a little bit of insulin> symptomatic hyperglycaemia >

… but usually resolves by 18 months

Question 19

child has type 2 neonatal diabetes,

when will they become hyperglycaemic?

Answer 19

during illness

Question 20

which type of neonatal diabetes is some insulin made (but only a little ovo)?

Answer 20

type 2