Module 9: Autoimmune Disease

Question 1

What is central tolerance?

Answer 1

Deletion of T and B cells that have specificity to self antigens
Occurs in bone marrow for B cells and in the thymus for T cells

Question 2

What is peripheral tolerance?

Answer 2

Mechanisms at the local level which induce a state of inactivity of lymphocytes even in the presence of antigen

Question 3

Antibody seen in Hashimoto’s Thyroiditis?

Answer 3

TPO antibody/Thyroglobulin antibody

Question 4

Antibody seen in myasthenia gravis?

Answer 4

Cholinesterase receptor antibody

Question 5

Antibody seen in SLE?

Answer 5

DNA, ANA, anti-SMA

Question 6

Antibody seen in graves disease?

Answer 6

TSH receptor antibody

Question 7

Antibody seen in rheumatoid arthritis?

Answer 7

Rheumatoid factor

Question 8

Antibody seen in insulin dependent diabetes mellitus?

Answer 8

Antibody to islet cell antigens

Question 9

Antibody seen in Goodpasture’s syndrome?

Answer 9

Basement membrane antibody

Question 10

Antibody seen in primary bilary cirrhosis?

Answer 10

Mitochondrial antibody