Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

HSCI 300 Immunology > Module 10: Tumor Immunology > Flashcards

Module 10: Tumor Immunology Flashcards

1
Q

Define neoplasm

A

Abnormal tissue with rapid and uncoordinated growth

Benign or malignant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Define cancer

A

Cellular malignant tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Define carcinoma

A

Cancer of epithelial origin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Define sarcoma

A

Cancer of connective tissue origin (bone, muscle, vessels)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Define leukemia/lymphoma/myeloma

A

Cancer of blood cell origin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Define tumor

A

Swelling of a defined mass of tissue

Benign or malignant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Define benign

A

Localized growth, not malignant or recurrent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Define malignant

A

Growth that becomes progressively worse due to the disruption of normal cell function, invasion of healthy tissue, and metastasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Define metastasis

A

Spreading form the primary location

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Define invasive

A

Moving from tissues surrounding the primary site

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Define protooncogene

A

Gene in a host cell which is involved in regulation of cell growth (proliferation, differentiation, survival)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Define oncogene

A

Gene that encodes a protein capable of inducing cellular transformation often through inappropriate cell growth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Tumor mechanisms to evade immune response (5)

A 
Non-immunogenic
Lack of adherence to lymphocytes
Immunosuppressive cytokines
Immunosuppressed
Induce T regs to suppress anti-tumor immune responses
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Major malignancy due to carcinoembryonic antigen (CEA) (oncofetal)

A

Colon cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Major malignancy due to alpha fetoprotein (AFP) (oncofetal)

A

Liver cancer, germ cell cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Major malignancy due to beta HCG (Human Chorionic Gonadotropin)

A

Germ cells tumors

17
Q

Major malignancy due to hepatitis B

A

Primary

Liver cancer

18
Q

Major malignancy due to human papilloma virus (HPV)

A

Cervical carcinoma

19
Q

Major malignancy due to Epstein-Barr virus (EBV)

A

Burkitt’s lymphoma

20
Q

Major malignancy due to HTLV-1 (viral)

A

Adult T cell leukemia

21
Q

Major malignancy due to calcitonin/thyroglobulin

A

Thyroid cancer

22
Q

Major malignancy due to RAS mutation

A

20-30% of human carcinomas, 90% or pancreatic cancers

23
Q

Major malignancy due to BCR/ABL

A

Chronic myelogenous leukemias

24
Q

Major malignancy due to Her-2/neu

A

Some breast cancers

25
Q

Major malignancy due to c-myc

A

Burkitt’s lymphoma

26
Q

Four types of immunotherapy

A

Vaccination
Enhancement of host immunity with cytokines and costimulators
Nonspecific immune system stimulation
Passive immunotherapy

HSCI 300 Immunology (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions