Module 8- Vitamins & Minerals Flashcards

1
Q

why is salt added by itself in diets?

A

do not want it to be deficient or inefficient

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2
Q

what would happen if too much salt was added to the diet? (2)

A

1) decrease feed intake
2) increase water intake

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3
Q

why can vitamins & minerals not be formulated at large feed mills?

A

scale tolerance is too large

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4
Q

what % of diet makes up the vitamin/mineral pre-mix

A

0.5%

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5
Q

T or F: vitamin/ mineral deficiencies are often secondary deficiencies with how they are mixed

A

T

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6
Q

how are vitamins defined?

A

if soluble polar solution

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7
Q

T or F: there is no relationship between B1 & B2 except for the order they were discovered

A

T

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8
Q

2 common features of minerals

A

1) insoluble, not readily absorbed
2) require carrier proteins for transport

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9
Q

T or F: minerals have to be solubilized in water prior to being fed

A

T

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10
Q

what 2 minerals ate soluble & do not form salts

A

iodine & selenium

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11
Q

T or F: minerals are protonated

A

T

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12
Q

protonated minerals form

A

salts

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13
Q

why must metal ions be chelated?

A

bc they are active so need to prevent oxidation in the body

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14
Q

metals form complexes with a well defined number of organic

A

ligands

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15
Q

ligand

A

molecule attached to metal ion

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16
Q

how do metal ions circulate in the body?

A

attached to a ligand, not free

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17
Q

what often acts as ligands for metal ions

A

AA

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18
Q

ligands consist of what 2 chemical groups

A

neutral or anionic

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19
Q

example of a ligand

A

chromium picolinate

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20
Q

why are mineral deficiencies not common?

A

bc they are stored in the body

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21
Q

what 2 minerals can be deficient? why?

A

Na & K, bc secreted in urine

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22
Q

where are macrominerals stored

A

bones

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23
Q

where are microminerals stored

A

liver

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24
Q

3 examples of macrominerals vs microminerals

A

macro- Ca, P & Mg
micro- Fe, Cu, Zn, Se, Cr

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25
Q

vitamins have been around for ( ) years

A

100

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26
Q

who discovered vitamins

A

casimir funk

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27
Q

vitamine

A

vital amine

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28
Q

vitamins

A

organic nutrients required in small quantities

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29
Q

T or F: vitamins must have an amine group for it to be a vitamin

A

F

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30
Q

T or F: vitamins cannot be synthesized by the body and must be supplied in the diet

A

T

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31
Q

what vitamin can somewhat be synthesized in the body in some animals

A

vitamin C

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32
Q

beriberi

A

thiamin

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33
Q

rickets

A

vitamin D

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34
Q

pelleagra

A

niacin

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35
Q

casimir funk won nobel prize in

A

1929

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36
Q

why are we seeing increased cases of scurvy?

A

moving away from traditional diets

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37
Q

T or F: all water soluble vitamins expect C were designated B vitamins at first

A

T

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38
Q

T or F: it is preferable to use the chemical name of B vitamins

A

T

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39
Q

T or F: storage of water soluble vitamins is very little besides B12

A

T

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40
Q

how are B vitamins absorbed in the gut at high vs low levels

A

high: passive absorption (osmotic)
low: sodium dependent active transport

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41
Q

why is it rare for water soluble vitamins to be toxic

A

bc they get excreted in urine

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42
Q

biotin is involved in

A

glucose metabolism

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43
Q

water soluble requirements for monogastrics vs ruminants

A

ruminants -> can synthesize all b vitamins but high producing dairy cattle cannot synthesize enough to support production

monogastrics-> can make in hindgut but no use to animal bc occurs after absorption

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44
Q

what horses may benefit from vitamin B supplements?

A
  • sick
  • hard working
  • racing
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45
Q

cecetropes

A

irregular feces, what is consumed from hindgut fermentation
- can get necessary vitamin B needs

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46
Q

fat soluble vitamins are defined by

A

non-polar hydrophobic molecules

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47
Q

what happens to fat soluble vitamins after absorption?

A

transported to liver in chylomicrons

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48
Q

high density lipoprotein

A

decrease fat, increase protein

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49
Q

VLDL

A

increase fat, decrease proteins

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50
Q

T or F: fat soluble vitamins can cause toxicity bc they can be stored

A

T

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51
Q

where are vitamins A, D E & K stored

A

liver & kidney

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52
Q

where is vitamin E stored

A

adipose tissue

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53
Q

how are fat soluble vitamins excreted

A

bile & feces

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54
Q

T or F: vitamin D is not a true vitamin

A

T

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55
Q

vitamin D is actually a hormone involved in

A

regulation of Ca & P metabolism

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56
Q

all fat soluble vitamins are ( ) derivates

A

isoprene

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57
Q

why is vitamin D not considered a true vitamin?

A

not essential bc body can synthesize it

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58
Q

rickets vs osteoporosis

A

rickets- young animals
osteo- older animals

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59
Q

rickets is a deficiency of

A

secondary deficiency of vitamin D, not calcium

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60
Q

most important group of vitamins & minerals

A

electrolytes

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61
Q

what 5 vitamins are electrolytes

A

Na, K, CI, Ca2+, Mg2+

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62
Q

electrolyte function

A

maintain Na/k gradient between intracellular/extracellular environment

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63
Q

Na/K ATPase pump

A

low intracellular Na, high K

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64
Q

how much ATP is used by the animal for maintenance of the Na/K ATPase pump?

A

1/3

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65
Q

what does P provide for the Na/K ATPase pump

A

high energy bonds provides energy for active transport

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66
Q

Na vs K toxicity symptoms

A

Na: coma, seizure
K: cardiac arrhythmia

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67
Q

T or F: Ca serves as a 2nd messenger to relay info from outside to inside the cell

A

T

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68
Q

2 methods of Ca absorption

A

1) active, transcellular
2) passive, paracellular

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69
Q

active absorption of Ca occurs when Ca is

A

low

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70
Q

solvent drag

A

when bring glucose into cell, some calcium is also brought in

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71
Q

passive absorption of Ca required activation of

A

SLGT-1 channel

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72
Q

passive absorption of Ca occurs in the ( ) when Ca levels are

A

jejunum & ileum, moderate to high

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73
Q

passive absorption in monogastric accounts for up to (%) absorption

A

50%

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74
Q

active absorption of Ca occurs in the ( ) when Ca is ( )

A

duodenum, low

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75
Q

synthesis of calbindin is controlled by

A

vitamin d

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76
Q

T or F: vitamin D is a relatively large protein with lots of Ca binding sites

A

T

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77
Q

active transport of Ca

A

into intestine, out into blood

78
Q

T or F: Ca excreted in feces is not in same form as consumed

A

T

79
Q

what is the major Ca binding factor in the blood?

A

gamma carboxyglutamate residues in albumen

80
Q

the production of gamma carboxyglutamate residues is catalyzed by

A

vitamin K

81
Q

circulation of Ca in blood is indirectly associated with level of

A

vitamin K

82
Q

high blood Ca stimulates

A

calcitonin

83
Q

calcitonin function

A

reduces bone resorption & intestinal Ca absorption, and increases urinary Ca excretion

84
Q

PTH function

A

increase bone resorption & intestinal Ca absorption, and decreases urinary Ca excretion

85
Q

skeletal Ca is in the form of

A

hydroxyapatite

86
Q

how many mg of Ca enters & leaves bones each day

A

500

87
Q

osteoclasts vs osteoblasts

A

clasts: remove Ca & P from bone
blasts: deposit Ca & P in bone

88
Q

osteoclast & osteoblast regulation is under ( ) control

A

hormonal

89
Q

T or F: Ca metabolism is precisely regulated

A

T

90
Q

PTH gland monitors blood Ca in the

A

carotid artery

91
Q

what is the rapid effect of PTH

A

decreases urinary Ca loss

92
Q

what is the primary hormone that regulates Ca resorption from bone

A

PTH

93
Q

PTH increases the number of

A

osteoclasts

94
Q

PTH is used for ( ) term regulation

A

long

95
Q

higher numbers of osteoclasts break down more bones = release

A

Ca

96
Q

vitamin D precursors are found in

A

plant & animal tissues

97
Q

once at the liver, vitamin D from the diet (can/cannot) be differeniated

A

cannot

98
Q

T or F: must supplement intensive livestock with vitamin D bc inside/no uV exposure

A

T

99
Q

net effect of vitamin D on Ca metabolism

A

higher blood Ca concentrations

100
Q

low estrogen can cause

A

osteoporosis

101
Q

what is the most abundant intracellular anion

A

P

102
Q

most P is absorbed in what form

A

inorganic

103
Q

low vs high P effects of vitamin D production

A

low = increase vitamin D
high= decrease vitamin D

104
Q

levels of P can vary up to what %

A

50%

105
Q

what 2 hormones regulate P

A

PTH & vitamin D

106
Q

T or F: P is not as tightly controlled as Ca

A

T

107
Q

when P is low = PTH secretion is

A

decreased = increases intestinal absorption of P

108
Q

ideal ratio of Ca : P

A

2 : 1

109
Q

T or F: excessive dietary P can interfere with Ca absorption in the small intestine

A

T

110
Q

high dietary P levels leads to large ( ) losses & ( )

A

fecal, bone resorption

111
Q

active form of vitamin D

A

calcitrol

112
Q

T or F: Ca is normally sufficient in plant sources

A

T

113
Q

T or F: Ca is cheap, P is expensive

A

T

114
Q

T or F: Ca has a max in diets

A

T

115
Q

inorganic P is derived from what 2 things

A

1) mineral sources
2) dicalcium phosphate

116
Q

where is organic P derived from

A

animal/plant sources

117
Q

what is the major P source in plants that is indigestible by animals

A

phytic acid

118
Q

T or F: it is difficult to distinguish deficiencies of Ca, vitamin D and P without blood tests

A

T

119
Q

cage layer fatigue is an example of a ( ) deficiency

A

Ca

120
Q

Pica symptoms

A

animals consume dirt & chew on pen materials

121
Q

T or F: Ca & P toxicity is quite common

A

F

122
Q

2 functions of vitamin K

A

1) blood clotting
2) cofactor for Gla synthesis

123
Q

what vitamin is in rat poisoning

A

vitamin K

124
Q

T or F: vitamin K deficiency is associated with osteoporosis

A

T

125
Q

T or F: newborns have large stores of vitamin K

A

F

126
Q

sweet clover poisoning in ruminants

A

coumarin is converted to dicoumarin which blocks vitamin K cycle

127
Q

T or F: ruminants typically require vitamin K supplements

A

F- is in plant materials

128
Q

what 2 things can happen if phytase enzymes are not fed

A

1) P will be overfed = more excreted
2) limiting in diet

129
Q

phytase functions (2)

A

1) lowers availability of P
2) decreases P excretion

130
Q

T or F: too much Ca can decrease activity of phytase

A

T

131
Q

how is P excreted in environment

A

phytic acid

132
Q

1 example of an energy associated vitamin

A

riboflavin

133
Q

coenzymes

A

small organic molecules required for catalytic activity of the enzyme

134
Q

all 5 energy associated vitamins are absorbed by what 2 ways

A

1) passive diffusion at high levels in the gut
2) sodium-dependent active transport at low levels in the gut

135
Q

active thiamin

A

thiamin diphosphate

136
Q

thiamin diphosphate function

A

coenzyme in reactions involving CO2 removal

137
Q

thiamin is an essential cofactor of multiple

A

mitochondrial dehydrogenase complexes

138
Q

pyruvate dehydrogenase is used in the ( ) cycle

A

glycolysis

139
Q

a-ketoglutarate dehydrogenase is used in the ( ) cycle

A

TCA

140
Q

thiamin deficiencies are related with ( ) disorders

A

neural

141
Q

rice bran contains what 2 vitamins

A

thiamin & riboflavin

142
Q

riboflavin functions as part of what 2 coenzymes

A

1) FAD
2) FMN

143
Q

FAD/FMN requiring pathways (3)

A

1) TCA
2) B-oxidation
3) electron transport chain

144
Q

beta-oxidation

A

breakdown of FA

145
Q

riboflavin deficiency is common bc it is low in what 2 feed sources for monogastrics

A

cereal grains & legumes

146
Q

T or F: riboflavin deficiency is not life threatening

A

T

147
Q

niacin is the generic name for

A

nicotinic acid & nicotinamide

148
Q

what AA can be converted to nicotinamide?

A

tryptophan

149
Q

60mg tryptophan = ( )mg niacin

A

1

150
Q

T or F: rumen bugs get source of N but not tryptophan

A

T

151
Q

example of niacin deficiency

A

pellagra

152
Q

pellagra

A

rough skin

153
Q

to produce a niacin deficiency, the diet must be low in

A

niacin and tryptophan

154
Q

what feed is low in niacin and tryptophan

A

corn

155
Q

biotin function

A

CO2 carrier in carbon dioxide fixation

156
Q

polyunsaturated fats ( ) biotin requirements

A

increase

157
Q

riboflavin requirements ( ) in high fat diets

A

increase

158
Q

acetyl-Coa carboxylase

A

converts acetyl units to FA

159
Q

avidin

A

protein in raw egg whites that binds biotin to make it unavailable

160
Q

pantothenic acid is part of coenzyme

A

A

161
Q

acetyl coenzyme A is used in

A

TCA cycle

162
Q

example of a pantothenic acid source

A

yogurt

163
Q

deficiency of pantothenic acid results in impaired

A

fat synthesis

164
Q

hematopoietic

A

involved in formation of blood cells

165
Q

3 examples of hematopoetic vitamins

A

folic acid, vita b12 & iron

166
Q

the only requirement for cobalt is for

A

vitamin b12

167
Q

deficiency of cobalt would show up as

A

vitamin b12 deficiency

168
Q

are plants or animal products a source of vitamin b12

A

animal

169
Q

vitamin b12 requires what 2 things to be absorbed

A

1) haptocorrin
2) intrinsic factor

170
Q

where is vitamin b12 stored

A

liver

171
Q

genetic disease for vitamin b12

A

have sufficient b12, but no IF = b12 is not absorbed properly

172
Q

why do people who do not eat animal products do not have a vitamin b12 deficiency?

A

storage in liver

173
Q

metabolism of b12 converts

A

homocysteine to methionine

174
Q

b12 deficiency results in ( ) because of ( )

A

megaloblastic anemia, reduced folate

175
Q

folic acid is required for

A

DNA synthesis

176
Q

in a vitamin b12 deficiency, folate (will/will not) be recycled so added folate will have ( ) effect

A

not, no

177
Q

cobalt requirements for ruminants

A

for rumen bacteria to synthesize vitamin B12

178
Q

what determines if Fe is ferric or ferrous?

A

pH

179
Q

in aqueous, aerobic environments iron is in form of

A

Fe3+ (ferric)

180
Q

iron is reduced to ( ) in acid stomach

A

fe2+

181
Q

intestinal absorption of iron requires

A

DMT1 transporter

182
Q

what is the only form iron can be absorbed as

A

Fe2+

183
Q

ferroportin vs transferrin

A

ferroportin: transports outside cell
transferrin: transports inside cell

184
Q

in blood, iron is circulating bound to

A

transferrin

185
Q

what form of organic minerals should be fed? why?

A

chelated form, bc not soluble

186
Q

absorption of heme iron is (%)

A

15-50%

187
Q

inorganic iron has what % of absorption

A

2-5%

188
Q

each globin in hemoglobin binds to 1 ( ) molecule

A

porphyrin

189
Q

T or F: almost no iron excretion

A

T

190
Q

why is iron not in free form

A

bc it is so reactive

191
Q

the level of saturation of ( ) in the blood is a good marker of iron status

A

transferrin

192
Q

ferritin reduces

A

free radicals