Module 8 Suffixes Flashcards
Glucocorticoids
“sone”
Betamethasone
Dexamethasone
Hydrocortisone
Prednisone
Cortisone
Prednisone
”- one”
Methylprednisolone
Prednisolone
Budesonide
Adrenocortical Agents
Enter target cells and bind to cytoplasmic receptors
Initiate many complex reactions responsible for anti-inflammatory and
immunosuppressive effects
Hydrocortisone, cortisone, prednisolone, and prednisone have some
mineralocorticoid activity
Mineralocorticoids
Cortisone
Fludrocortisone
Hydrocortisone
Prednisone
Prednisolone
Adrenocortical Agents
Holds sodium, and with it, water in the body
Causes the excretion of potassium by acting on the renal tubule
Interferons
Interferon alfa-2b
Immune Modulators - stimulants
Preventing virus particles from replicating inside other cells
Stimulating interferon receptor sites on noninvaded cells to produce antiviral
proteins
Interleukins
Aldesleukin
Oprelvekin
Immune Modulators - stimulants
Increase the number of natural killer cells and lymphocytes
Activates cellular immunity and inhibits tumor growth
Increases circulating platelets
Colony-Stimulating Factors
“-stim” in the name
Filgrastim
Pegfilgrastim
Immune Modulators - stimulants
Increase the production of neutrophils in the bone marrow with
little effect on other hematopoietic cells
Immune modulators
Apremilast
Immune Modulators - suppressants
Inhibit the secretion of proinflammatory cytokines and increase the secretion of anti-inflammatory cytokines from monocytes and have varying effects on
cell proliferation
T- and B-Cell Suppressors
Cyclosporine
Mycophenolate
Tacrolimus
Immune Modulators - supressors
Block antibody production by B cells, inhibit suppressor and helper T cells,
and modify the release of interleukins and T cell growth factor
Interleukin Receptor Antagonist
Anakinra
Immune Modulators - supressors
Blocks the activity of the interleukins that are released in an inflammatory or
immune response
Monoclonal Antibodies
(-mab)
Adalimumab, certolizumab, golimumab, and infliximab
Immune Modulators - supressors
It reacts as an antibody to human T cells, disabling the T cells
and acting as an immune suppressor
Salicylates
Aspirin and Mesalamine
Anti-inflammatory, Antiarthritis, and Related Agents
Inhibit synthesis of prostaglandin, used to treat mild to moderate pain and fever
Nonsteroidal Anti-
inflammatory Drugs (NSAIDs)
Propionic Acids
○Ibuprofen
○Naproxen
Acetic Acids
○Indomethacin
○Ketolorac
Oxicam derivatives
○Meloxicam
Cyclooxygenase-2 Inhibitors
○Celecoxib
Anti-inflammatory, Antiarthritis, and Related Agents
Block two enzymes, known as COX-1 and COX-2
Gold Compounds
Auranofin
Anti-inflammatory, Antiarthritis, and Related Agents
Absorbed by macrophages, which results in inhibition of phagocytosis
Tissue destruction is decreased
Disease Modifying
Antirheumatic Drugs (DMARDs)
“-mab”
Dalimumab
Infliximab
Etanercept - receptor fusion protein
Anti-inflammatory, Antiarthritis, and Related Agents
Act to decrease the local effects of TNF, a locally released cytokine that can cause
the death of tumor cells and stimulate a wide range of proinflammatory activities
Antigout Agents
Allopurinol & colchicine
Anti-inflammatory, Antiarthritis, and Related Agents
Decreases inflammation by blocking the action of neutrophils (colchicine)
Inhibit xanthine oxidase, which is an enzyme needed to convert xanthine to
uric acid (allopurinol
