Module 7: Multiple Sclerosis Flashcards

0
Q

Environmental risk factors for multiple sclerosis?

A
#Vitamin D deficiency
#EBV
#Cigarette smoking
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Neuromyelitis optica – antigen? Symptoms?

A

“Bad MS”

Aquaporin 4 on astrocyte

Bilateral optic neuritis and visual loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Location of lesions in multiple sclerosis? Dawsons fingers?

A

Periventricular and subcortical regions

lesions travel along veins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Classifications of multiple sclerosis?

A
#Relapsing and remitting
#Secondary progressive – fever overt relapses with time but slowly gets worse
#Primary progressive – no acute episodes
#Progressive relapsing – continues to get worse with episodes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Why do new MS lesions appear on imaging?

A

Breakdown of blood brain barrier causes contrast enhancing lesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Findings in optic neuritis?

A

Pain and loss of visual acuity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CSF findings in MS?

Another diagnostic test?

A
#Oligoclonal bands in CSF (that are not present in serum)
# increased IgG index and positive OCB 

Visually evoked potentials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Treatment of relapses of MS?

If severe?

A
#High-dose IV steroids (if cannot be used, oral prednisone or ACTH)
#IVIG

if severe, plasma exchange

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

First-line long-term treatment agents for multiple sclerosis?

A
#Interferons for relaxing/remitting (nothing approved for progressive)
#Glatiramer Acetate
#Monoclonal antibodies
How well did you know this?
1
Not at all
2
3
4
5
Perfectly