Module 6 - renal

Question 1

Hallmark of Henoch-Schönlein Purpura

Answer 1

IgA deposition in the small vessels of the superficial dermis - detected via skin biopsy

Question 2

Clinical features of nephrotic syndrome

Answer 2

Proteinuria
Hypoalbuminuria
Oedema

high c3

Question 3

Clinical features of nephritic syndrome

Answer 3

haematuria
puffy eyes or swollen ankles
oligouria

low C3 that normalises in 3-4 weeks

Question 4

Features of Henoch-Schönlein Purpura?

Answer 4

skin rash on buttocks and extensor surface of arms and legs
arthralgia/arthritis
periarticular oedema
abdominal pain
glomerulonephritis

Question 5

Complications of nephrotic syndrome

Answer 5

thrombosis - hypercoagulable state (lose protein C and S)
cellulitis
hypertension
hypovolemia - loss of intravascular fluid
bleeding

Question 6

Treatment of nephrotic syndrome

Answer 6

Steroid daily for ~4 weeks until proteinuria is 0 or 1+ then wean down the amount of steroid via alternating days (over a few weeks).

Consider albumin and frusemide