Module 6: Bone: Osteoclastoma and Ewing's Sarcoma Flashcards

1
Q

The next tumor is a benign tumor called Osteoclastoma (giant cell tumor), what is the etiology?

A

Affects 20-40 yr olds

  • -can be due to Paget’s disease
  • -origin is mesenchyme (Stromal cell of bone)
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2
Q

What is the pathogenesis for Osteoclastoma (Giant cell tumor)?

A

Arises from the epiphysis location of distal femur and proximal tibia (like the chondroblastoma)
–benign tumor of mesenchyme with locally invasive malignant properties

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3
Q

What is the presentation for a patient with osteoclastoma?

A

20-40 yr old person with arthritis like symptoms

–commonly affects the knee

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4
Q

What is seen on biopsy for a patient with osteoclastoma?

A

Multinucleated osteoclast-like giant cells (Reactive) and neoplastic mononuclear stromal cells
(reacting macrophages coming together - giant cells)
–Neoplastic cells are mono-nucleated cells between giant cells from stroma - considered benign

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5
Q

What is seen on gross and xray in a patient with osteoclastoma?

A

Gross: hemorrhagic and cystic and necrosis

X-ray: Soap bubble appearence bc its very cystic and radiolucent

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6
Q

What are complications of Osteoclastoma?

A

Even though its benign it has malignant properties: can invade and mets through blood and lungs

  • -can locally invade (locally aggressive) and recurs after removal
  • -can be associated with Paget’s disease of bone (most common tumor is osteosarcoma but can also get osteoclastoma)
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7
Q

The last bone tumor to touch on is Ewing’s Sarcoma. What is the etiology?

A

t (11:22) – more common – and t (21:22) in diaphysis of children (less than 20 years old and in boys)
Part of PNET: primitive neuroectodermal tumor (also medulloblastoma in PEDS)

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8
Q

What bones are affected in Ewing’s Sarcoma?

A

Arises from diaphysis

  • -affects long bones (Femur, tibia, humerus, ulna and radius)
  • -femur most common site
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9
Q

What is seen on histology in patients with Ewing’s sarcoma?

A

Sheets of small round blue cells with small amount of clear cytoplasm
–sometimes seen is pseudorossetes (seen in neuroblastoma)

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10
Q

What is seen on biopsy in patients with Ewing’s Sarcoma?

A

Onion skin appearance (invasion of periosteum)

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11
Q

What is the prognosis for patients with Ewings sarcoma?

A

Dismal (improves with chemo)

–spreads through medullary cavity to cortex then periosteum then to blood and lungs

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