Module 2: GI: Oral Cancers and Esophageal Non-Cancer Pathologies Flashcards
First lets start off with the basics of GI. What are signs and symptoms of upper GI disease?
Dysphagia Epigastric pain Heartburn, dyspepsia, and flatulence Loss of appetite Nausea and Vomiting Hematemesis
What are signs and symptoms of lower GI disease?
Colicky abdominal Pain Abdominal Distention Diarrhea Constipation Blood in Stools: Occult (Guaiac test) , Hematochezia and Melena Anemia
What are signs and symptoms of upper and lower GI disease?
Epigastric tenderness/mass Heptaomegaly Splenomegaly Ascites Visible peristalsis Abdominal rigidity/guarding
The first topic to be discussed is issues with the oral cavity. What are the two types of leukoplakia?
- Oral Hairy Leukoplakia: not dysplastic
- -Associated with EBV and seen in HIV patients
- -No malignant potential
- –Histology: hyperkeratosis (epidermal thickening of the stratum corneum) with acanthosis - Oral Leukoplakia: dysplastic but BM is intact
- -Pre-malignant in 5% and cannot be scraped off
- –pre-disposing factors: tobacco use, ill-fitting dentures and HPV (slide 1a)
What is Erythroplakia?
Erythroplakia aka erythroplasia:
- –dysplastic but BM is intact
- –Pre-malignant: over 50% of patients
- -much higher chance of becoming malignant
- -less common
- -poorly circumscribed
Next we move on to oral cancer. What are the two morphologies for oral carcinoma?
Exophytic: growing outward like a mushroom, fungating; presents early (seen in pic in lab)
Endophytic: grows inwards, more dangerous
What does the histology for oral carcinoma look like?
Squamous cell carcinoma with well differentiated keratin pearls
—seen on excisional biopsy
What are the top 3 locations for oral carcinoma?
- Vermilion border of lower lip
- Floor of the mouth
- Lateral Boarder of the tongue (seen in pic 2)
What are the predisposing factors for oral carcinoma?
Tobacco Chewing (most common) Alcohol Jagged Teeth Ill-fitting dentures HPV (16 & 18) -more common in men than women
What is the presentation for oral carcinoma?
Asymptomatic
pain on chewing
What would a biopsy for oral carcinoma show?
Malignant squamous cells with keratin pearls
Oral carcinoma spreads via the lymphatics, which lympathetics?
Anterior cervical lymph nodes
Now moving on to esophageal lesions. The first one to speak about is a congenital malformation called esophageal atresia, what is the etiology?
Disruption of elongation and separation of esophagus and trachea during embryogenesis —- leads to a tracheo-esophageal fistula.
What is esophageal atresia associated with?
Maternal polyhydramnios, single umbilical artery (this is the one he stressed in class)
What is the presentation of a newborn with esophageal atresia?
Choking and cyanosis after infant’s first feeding
Excessive drooling of saliva in new born
Now moving onto the non neoplastic conditions in the esophagus. What is a hiatal hernia?
Stomach protrudes through an enlarged esophageal hiatus in the diaphragm
What is the presentation of a hiatal hernia?
Reflux of gastric contents due to incompetence of LES
–gastric contents literally go into the esophagus